Arizona Diamondbacks vs Chicago Cubs Picks and Prediction for Sunday May 3 2026
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The Arizona Diamondbacks will face the Chicago Cubs at Wrigley Field in Chicago, Illinois, on Sunday, May 3, 2026, at 2:20 PM. The game will be broadcast on MLB.TV, with Arizona entering at 16-15 overall and 7-9 on the road, while Chicago comes in at 20-12 overall and a strong 12-5 at home. At the time of this writing the odds were not released. For a deeper look at today’s slate and additional betting angles, visit the latest MLB picks.
Starting Pitchers
Arizona is expected to start Merrill Kelly, while Chicago is set to counter with Matthew Boyd. Kelly enters with a 1-2 record, a 9.20 ERA, a 2.25 WHIP, 14.2 innings pitched, 21 hits allowed, nine strikeouts, 12 walks, and five home runs allowed. Boyd comes in at 1-1 with a 7.00 ERA, a 1.44 WHIP, 18.0 innings pitched, 21 hits allowed, 26 strikeouts, five walks, and one home run allowed. Both pitchers have struggled with run prevention, though Boyd holds the edge in strikeouts and control. 
Arizona Looking to Find Stability on the Road
The Diamondbacks come into this game with a 16-15 record and a 7-9 mark away from home. Arizona has gone 2-3 over its last five games, recently losing to Chicago and Milwaukee twice while picking up wins over Milwaukee and San Diego. The most recent result was a narrow 6-5 loss to the Cubs, showing that these teams have already been competitive against each other in this series.
Arizona is batting .251 with 146 runs, 261 hits, and 32 home runs, along with a .308 on-base percentage and a .418 slugging percentage. On the pitching side, the Diamondbacks have a 5.04 ERA and a 1.39 WHIP, with 106 walks, 227 strikeouts, and a .259 opponent batting average. These numbers show a team that can generate offense but has struggled to limit opposing scoring.
A key weakness for Arizona is its pitching. With a 5.04 ERA and a .259 opponent batting average, the Diamondbacks have had difficulty preventing runs, which puts added pressure on their offense to keep pace in games.
Chicago Bringing Strong Home Form Into This Matchup
The Cubs enter this contest with a 20-12 record and an impressive 12-5 record at home. Chicago has won three of its last five games, recently defeating Arizona and San Diego twice while losing to San Diego and Los Angeles. The most recent result was a 6-5 win over Arizona, continuing their success in this matchup.
Chicago is batting .260 with 175 runs, 287 hits, and 42 home runs, along with a .352 on-base percentage and a .425 slugging percentage. The pitching staff has a 4.04 ERA and a 1.20 WHIP, with 96 walks, 264 strikeouts, and a .231 opponent batting average. These numbers reflect a well-rounded team with both offensive and pitching advantages.
Chicago’s key strength is its balance. The Cubs lead Arizona in runs, hits, home runs, on-base percentage, and slugging percentage, while also holding better pitching numbers across ERA, WHIP, and opponent batting average. This combination gives Chicago a consistent edge in controlling games.
Arizona Diamondbacks vs Chicago Cubs Picks and Prediction
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Bryan Power | +4,192.00 |
| 2 |  Bruce Marshall | +4,189.00 |
| 3 |  Joe Duffy | +2,213.00 |
| 4 |  Sniper Wes | +1,832.00 |
| 5 |  Tom Macrina | +1,044.00 |
Arizona Diamondbacks vs Chicago Cubs Pick
- Pick: Chicago Cubs Moneyline
Chicago is the pick based on its stronger overall profile and home performance. The Cubs have the advantage in both offensive production and pitching metrics, while also holding a 12-5 record at home. Arizona’s pitching struggles, including a higher ERA and WHIP, make it difficult to trust them in this matchup. With Chicago already securing a recent win in this series, the data supports the Cubs as the stronger side.
Arizona Diamondbacks vs Chicago Cubs Total Pick
- Pick: Take the over if the total is set at 9.0.
I would lean over if the total is set at 9.0 because both teams have shown the ability to score runs, and both starting pitchers have elevated ERAs. Arizona has allowed consistent scoring due to its pitching struggles, and Chicago’s offense has been productive with 175 runs and 42 home runs. With both teams capable of contributing offensively, the conditions suggest a higher-scoring game.
Final Score Prediction: Chicago Cubs 7 – Arizona Diamondbacks 5
This prediction was written before the completion of game play on Saturday.
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