Arizona Diamondbacks vs Chicago Cubs Picks and Predictions for Friday, May 1, 2026
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Diamondbacks vs Cubs Game Information
The Arizona Diamondbacks will be on the road Friday afternoon for game 1 of 3 inside Wrigley Field at 2:20 PM against the Chicago Cubs. The Arizona Diamondbacks come into this matchup with 16 wins and 14 losses overall, having lost 3 of the last 5 following a 12-run road loss to the Milwaukee Brewers. The Chicago Cubs return home Friday, 7 games above .500 this season with 19 wins, riding a 2-game winning streak after a 1-run road victory against the San Diego Padres. Stay in the news with our MLB Picks.
Diamondbacks Preview
Offensively, Arizona has been solid this season with a .252 batting average. The Diamondbacks have scored 140 runs on 244 hits. Arizona has a .310 OBP and a .425 team slugging percentage. Arizona's pitching has been the biggest issue, boasting a 4.72 team ERA. Ildemaro Vargas leads the Arizona offense this season with a .378 batting average, 6 home runs, and 20 RBI's on the year. 
Cubs Preview
The Chicago Cubs offense has been stout this season, with a .261 batting average. The Cubs have scored 169 runs on 279 hits. The Chicago power has been resounding as well, with 42 home runs and a .472 team slugging percentage. Chicago's pitching has been mediocre this season, with a 4.01 ERA, and they have allowed 7 runs during their current 2-game winning streak. Nico Hoerner leads the Chicago offense this season with a .291 batting average and 26 RBI's. Ian Happ has a .230 batting average and leads Chicago with seven home runs this season.
Diamondbacks vs Cubs Pitching Matchup
Zac Gallen will take the mound Friday for the Diamondbacks, 1-1 on the year with a 3.14 ERA through 28.2 innings of work. The Chicago Cubs will counter with Colin Rea. Rea has 3 wins and 1 loss this season, along with a 4.61 ERA across 27.1 innings of action.
Diamondbacks vs Cubs Pick
Both teams played well enough thus far this season, but Chicago will have the edge on Friday. Look for the Cubs to thrive in front of their home fans as they use the better offense to do the job. Take Chicago on Friday afternoon to start this series with a win against a solid Arizona Diamondbacks team.
- Pick: Chicago Cubs - 136
- Secondary: Over
- Lean: Nico Hoerner Over. 5 RBIs
Final Score Prediction: Chicago Cubs win 7-5.
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