Arizona Diamondbacks vs Houston Astros Picks and Predictions for Saturday, September 5th, 2026

By: Cameron Ross Published 09/05/2026, 12:25 AM ET

Arizona Diamondbacks vs Houston Astros Game Information

The Astros will stay in Houston, TX, Saturday night for a 7:15 PM game inside Daikin Park against the Arizona Diamondbacks. Arizona is a few games above .500, currently the second-best team in the National League West coming into this matchup. The Houston Astros are hovering around .500 coming into Saturday, currently competing for the top spot in the American League West standings. For more MLB news, see our MLB Picks.

Arizona Diamondbacks Preview

The Arizona offense has a .243 batting average this season, scoring 628 runs on 1145 hits. Arizona has a .315 OBP and .395 team slugging percentage. The Arizona bullpen has posted a 4.16 team ERA this season. Gabriel Moreno leads Arizona this year with a .298 batting average. Nolan Arenado has a .234 batting average and leads the team with 21 home runs. Ketel Marte has a .251 batting average and leads Arizona with 67 RBIs.

Houston Astros Preview

The Houston Astros offense has a .240 batting average this season, scoring 639 runs on 1137 hits. Houston has a .315 OBP and a .408 team slugging percentage. Houston's pitching has been terrible, with a 4.56 team ERA this season. Jordan Alvarez does everything for Houston, leading the team with a .316 batting average, 37 home runs, and 94 RBIs as he pursues the Triple Crown.

Arizona Diamondbacks vs Houston Astros Pitching Matchup

Arizona has yet to name a starter in this matchup and could rely heavily on their bullpen Saturday night. The Houston Astros will turn the ball over to Ethan Pecko for Game 2 of this set. Pecko is 1-0 this year despite a 6.23 ERA across 13 innings.

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Arizona Diamondbacks vs Houston Astros Pick

Both teams come into Saturday desperately needing wins as each is pursuing a playoff berth. Look for Houston to do the job on their home field Saturday to get the win, as Arizona's road struggles will continue. Take the Astros to pull off the victory Saturday night as they continue their push towards a division title.

  • Pick: Houston Astros
  • Secondary: Over
  • Lean: Arizona Diamondbacks

Final Score Prediction: Arizona Diamondbacks win 5-1.

Game Written Before completion of the game on Friday.

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