Athletics vs Cleveland Guardians Picks and Predictions for Sunday, September 20th, 2026

By: Cameron Ross Published 09/20/2026, 03:10 AM ET

Athletics vs Cleveland Guardians Game Information

The Athletics will finish a 3-game road series Sunday afternoon with a 1:40 PM matchup at Progressive Field in Cleveland against the Cleveland Guardians. The Athletics are well below .500 and sit fourth in the American League West. Cleveland is 4 games above .500 and currently holds first place in the American League Central standings. For more MLB action, see our MLB Picks.

Athletics Preview

The Athletics offense has a .244 batting average this season, scoring 661 runs on 1267 hits. The Athletics have posted a .317 OBP and a .402 team slugging percentage. Their pitching staff has struggled all season, posting a 5.41 team ERA. Jeff McNeil leads the Athletics with a .268 batting average, while Shea Langeliers has a .263 batting average and leads the team with 23 home runs. Nick Kurtz bats .256 and leads the roster with 69 RBIs.

Cleveland Guardians Preview

Cleveland enters this matchup with a .237 team batting average, producing 636 runs on 1216 hits. The Guardians have a .315 OBP and a .375 slugging percentage this season. Chase DeLauter leads Cleveland with a .289 batting average. Angel Martinez has hit a team-best 15 home runs, while Brayan Rocchio has a .250 batting average and leads the Guardians with 69 RBIs.

Athletics vs Cleveland Guardians Pitching Matchup

Jack Perkins will start for the Athletics. Perkins is 3-11 with a 6.14 ERA and a 1.48 WHIP across 110 innings, recording 127 strikeouts while allowing 115 hits, 48 walks, and 20 home runs. Gavin Williams will counter for Cleveland. Williams enters at 13-8 with a 3.78 ERA and a 1.10 WHIP through 174 innings. He has collected 235 strikeouts while surrendering 136 hits, 56 walks, and 27 home runs.

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Athletics vs Cleveland Guardians Pick

Cleveland has a significant advantage on the mound with Williams facing a struggling Perkins. The Athletics starter has allowed too many runners and carries an ERA above 6.00, creating a favorable opportunity for the Guardians to score early. Williams should limit an Athletics team that has struggled throughout the season. Look for Cleveland to take control during the opening innings and secure the home victory.

  • Pick: Cleveland Guardians
  • Secondary: Over
  • Lean: Chase DeLauter Over 1.5 Bases

Final Score Prediction: Cleveland Guardians win 7-3

Game Written Before Completion of the Game on Saturday

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