Athletics vs San Diego Padres Picks and Prediction for Sunday May 24 2026

By: Kim Smith Published 05/24/2026, 12:20 AM ET
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The Athletics travel to Petco Park in San Diego to face the San Diego Padres on Sunday, May 24, 2026, with first pitch scheduled for 4:10 PM ET on MLB.TV. The Athletics enter the matchup with a 26-25 record while San Diego comes into the game at 30-20 overall. At the time of this writing the odds were not released. Be sure to check out our free MLB picks

Starting Pitchers Taking the Mound

Jacob Lopez gets the start for the Athletics in this matchup. The left-hander enters with a 3-2 record along with a 6.14 ERA and 1.80 WHIP across 44 innings pitched. He has allowed 49 hits and 11 home runs while recording 32 strikeouts and 30 walks this season. San Diego counters with Michael King, who carries a 4-2 record with a 2.31 ERA and 1.06 WHIP over 58.1 innings. King has allowed only 38 hits and four home runs while striking out 59 batters this year.

Athletics Looking to Bounce Back on the Road

The Athletics enter this matchup with a 26-25 overall record and a solid 16-13 road mark this season. They recently lost to San Diego 7-3 but had previously recently won over the Angels three times during a productive stretch in Anaheim. The Athletics scored 14 runs in one of those victories and also picked up consecutive extra-inning wins before arriving in San Diego. Despite the recent setback, the team has still played competitive baseball over the last several games.

The Athletics are batting .249 as a team with 227 runs scored, 433 hits, and 54 home runs this season. They have posted a .329 on-base percentage and a .396 slugging percentage while also recording 401 strikeouts from the mound. On the mound, the Athletics hold a 4.33 ERA with a 1.41 WHIP while allowing opponents to hit .252 against them this season.

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One important strength for the Athletics has been their ability to generate offense consistently throughout the lineup. The club has already produced 227 runs and 433 hits this year while maintaining respectable on-base production. However, the pitching staff has struggled at times with a 4.33 ERA and elevated WHIP, which could become difficult against a San Diego pitching staff that has been more efficient overall.

Padres Trying to Continue Strong Season at Home

San Diego enters this matchup with a 30-20 overall record and a 15-12 mark at home this season. The Padres recently won over the Athletics 7-3 and have split their last five games overall. During that stretch, San Diego also recently won over Seattle twice while recently lost to the Dodgers in consecutive games before returning home. The Padres have continued to stay competitive despite some recent offensive inconsistency.

The Padres are batting .221 as a team with 207 runs, 361 hits, and 52 home runs this season. San Diego owns a .293 on-base percentage and a .369 slugging percentage while maintaining a strong 3.91 team ERA and 1.25 WHIP. Opponents are hitting only .234 against the Padres pitching staff, and the club has recorded 434 strikeouts this season.

The biggest strength for San Diego entering this matchup has been its pitching consistency. The Padres continue to limit opposing offenses effectively while keeping opponent batting averages low. The strikeout production and overall run prevention numbers have helped San Diego remain successful even during stretches where the offense has not produced heavily.

Athletics vs. San Diego Padres Picks and Prediction

Athletics vs. San Diego Padres Pick

  • Pick: San Diego Padres Moneyline

San Diego enters this matchup with the stronger overall pitching profile and the advantage on the mound in this game. The Padres also recently won over the Athletics 7-3 in the opening game of this series while continuing to limit opposing hitters effectively throughout the season. The Athletics have shown offensive production recently, but the difference in pitching numbers gives San Diego the edge entering Sunday afternoon.

Athletics vs. San Diego Padres Total Pick

  • Pick: Over 6.5

I am leaning toward the under in this matchup because of San Diego’s pitching strength and the strong season numbers from Michael King. The Padres have maintained a 3.91 ERA while opponents are batting only .234 against them this year. While the Athletics have played in some higher-scoring games recently, San Diego’s pitching staff has consistently kept games under control. This matchup feels more likely to stay lower scoring at Petco Park.

Final Score Prediction: San Diego Padres 4 – Athletics 1

This prediction was written before the completion of game play on Saturday.

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