Atlanta Braves vs Washington Nationals Picks and Predictions for Wednesday April 22 2026
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The Atlanta Braves and Washington Nationals are set to face off at Nationals Park in Washington, District of Columbia on Wednesday, April 22, 2026, with first pitch scheduled for 6:45 PM and coverage available on MLB.TV. The betting odds list Atlanta as a -149 favorite on the moneyline, while Washington comes in at +123. The total is set at 9 runs, with the over priced at -105 and the under at -115. On the run line, the Braves are -1.5 at +113, while the Nationals are +1.5 at -136. Make sure to check out free MLB picks.
Starting Pitchers Taking the Mound
Martin Perez will start for Atlanta, bringing a 1-1 record, a 2.21 ERA, and a 0.93 WHIP over 20.1 innings. He has allowed 13 hits, struck out 10, walked 6, and given up 1 home run. On the other side, Zack Littell gets the ball for Washington with a 0-2 record, a 7.11 ERA, and a 1.74 WHIP across 19 innings. He has allowed 27 hits, recorded 14 strikeouts, issued 6 walks, and surrendered 7 home runs.
Braves Carrying Momentum on the Road
Atlanta enters this matchup with a strong 16-7 record and an impressive 8-3 mark on the road. The Braves have been on a dominant run recently, recently winning over Washington 9-4 and also securing victories over Philadelphia in multiple games, including 4-2, 3-1, and 9-0. They also recently won over Miami 6-3, making it a clean sweep of their last five games. That stretch highlights a team that has been playing with confidence and consistency.
From a statistical standpoint, Atlanta has been highly productive, hitting .274 with 131 runs, 218 hits, and 30 home runs. The Braves have posted a .342 on-base percentage and a .446 slugging percentage. On the pitching side, they carry an impressive 2.68 ERA and a 1.05 WHIP, while holding opponents to a .205 batting average. The staff has also recorded 186 strikeouts with just 64 walks.
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One of the biggest strengths for Atlanta is its complete performance across both offense and pitching. The combination of a high batting average, strong power numbers, and one of the lowest ERAs in this matchup makes them a difficult team to slow down.
Nationals Hoping to Find Stability at Home
Washington comes into this game with a 10-13 record and a 2-8 mark at home. The Nationals recently lost to Atlanta 9-4 but have had mixed results over their last five games. They recently won over San Francisco 3-0 and also picked up an 8-7 extra-inning victory against Pittsburgh, but they have also recently lost to San Francisco and Atlanta during that stretch. That inconsistency has been reflected in their overall record.
Offensively, Washington is hitting .252 with 125 runs, 203 hits, and 25 home runs. The Nationals have posted a .327 on-base percentage and a .400 slugging percentage. On the pitching side, they hold a 5.71 ERA and a 1.54 WHIP, while allowing opponents to hit .269. The staff has recorded 178 strikeouts and issued 98 walks.
A major concern for Washington has been its pitching struggles. The elevated ERA and WHIP show that opponents have been able to generate offense consistently, which has made it difficult for the team to capitalize on its solid offensive production.
Atlanta Braves vs Washington Nationals Picks and Prediction
Atlanta Braves vs Washington Nationals Pick
Pick: Atlanta Braves -1.5
Atlanta’s combination of strong offense and efficient pitching gives them a clear edge in this matchup. The Braves have been scoring at a high level while also limiting opponents with a 2.68 ERA and a .205 opponent batting average. Washington’s pitching struggles, highlighted by a 5.71 ERA and a 1.54 WHIP, create a situation where Atlanta should be able to generate consistent offense. With the Braves already recently winning over the Nationals in this series, the run line becomes an appealing option.
Atlanta Braves vs Washington Nationals Total Pick
Pick: Over 9
I’m leaning toward the over in this game because of Washington’s pitching difficulties and Atlanta’s offensive production. The Braves have been scoring consistently, and the Nationals’ higher ERA suggests they may have trouble containing that lineup. At the same time, Washington has shown the ability to score with a .252 team batting average and 125 runs. That combination points toward a game where both teams can contribute to the total.
Final Score Prediction: Atlanta Braves 7 – Washington Nationals 4
This prediction was written before the completion of game play on Tuesday.
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