Baltimore Orioles vs Chicago White Sox Picks and Predictions for Tuesday, September 16, 2025
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The Baltimore Orioles visit the Chicago White Sox at Guaranteed Rate Field on Tuesday at 7:40 p.m. ET on MLB.TV. Baltimore is 69–80 (33–42 away) and Chicago is 57–93 (32–43 home). Baltimore lost to Toronto 11-2 on Sunday, and the White Sox fell to the Guardians 3-2. Chicago has been eliminated from postseason contention, and Baltimore is on the verge of being eliminated. Swing for the fences with our MLB Free Picks.
Baltimore Orioles Preview
Baltimore has dropped three straight after taking two from Pittsburgh, and the offense has been streaky all season: .239 avg, .306 on-base percentage, .399 slugging percentage with 176 home runs. Gunnar Henderson leads the lineup in average (.271) and RBI (62), while Jackson Holliday paces the club in homers (17). Depth has been tested with Adley Rutschman on the 10-day IL.
Tyler Wells will start on the mound for Baltimore (1–0, 2.31 ERA, 0.60 WHIP, 11.2 IP, 10 K, 1 BB, 2 home runs allowed). It’s a small sample due to missing most of the season with an injury, but Wells has had good control and kept runners off base. Baltimore pitching (4.63 ERA, 1.38 WHIP) is behind Chicago’s, making first-pitch strikes and keeping the ball in the yard the keys for Wells.
Chicago White Sox Preview
Chicago has lost three straight after a brief two-game winning streak versus Tampa Bay. As a team this season, Chicago is (.234/.303/.375, 151 home runs), but Lenyn Sosa has been solid (20 home runs, 68 RBI, .263 avg). The Sox haven’t been sharp in day games (26–40), yet they match up better here if they can be patient at the plate, get on base, and have timely hitting.
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Shane Smith starts on the mound (6–7, 3.78 ERA, 1.18 WHIP, 131.0 IP, 122 K, 53 BB, 16 home runs allowed). He limits hits and has kept home runs to a minimum. Against a Baltimore lineup missing key hitters and lacking in power, Smith needs to get ahead, avoid issuing walks, and make the Baltimore string together hits. Chicago’s pitching staff (4.21 ERA, 1.36 WHIP) has performed better than Baltimore’s.
Baltimore vs Chicago Prediction
Take the Chicago White Sox to win. Chicago’s starter has the steadier track record, and the Sox have a small edge in the bullpen. Baltimore could be dangerous if Henderson and Holliday make good contact, but with the O’s are on a cold stretch and down key hitters. Final Score Prediction: Chicago White Sox win 5-3.
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Best Pick
- Chicago White Sox +125
