Baltimore Orioles vs New York Yankees Picks and Prediction for Saturday September 27 2025

By: Eddie Kline Published 09/27/2025, 01:00 AM ET

Orioles Preview

The Saturday MLB schedule will get underway with a matinee between the Baltimore Orioles and the New York Yankees from the Bronx. Be ready for the baseball season with all of our MLB predictions. The Orioles (75-85) are seven games below .500 on the road and will finish the season in the AL East Division basement. Last night, Baltimore 3B Jordan Westburg hit a three-run blast and OF Tyler O’Neill added a solo shot during an 8-4 road loss against New York.

Thirty-five year old righty Tomoyuki Sugano (10-9 4.54 ERA) has hit the wall in his first major league season. The Orioles have dropped Sugano’s previous five starts and he has surrendered 20 runs across his last 21 plus frames.

Yankees Preview

The New York Yankees are riding a six-game winning streak and are tied with Toronto atop the AL East Division standings. During Friday’s home victory, DH Giancarlo Stanton homered twice and drove in five runs to lead the New York offense. All-Star OF Aaron Judge added his 52nd long ball of the year for the Yankees (92-68), who moved to 48-31 at home.

Rookie right-hander Cam Schlittler (3-3 3.27 ERA) will make his 14th career major league start for the Yankees. Through 66 innings of work, Schlittler has fanned 75 batters and owns a respectable 1.30 WHIP.

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Orioles vs Yankees Pick

Baltimore C Gary Sanchez (knee) is currently on the 10-day injured list and will not play in this series. Through 160 games, Baltimore ranks 21st in OPS and 23rd in runs scored. For the season, New York ranks 1st in OPS and 1st in runs scored. Take the under. Final Score Prediction, New York Yankees win 5-2.

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