Baltimore Orioles vs New York Yankees Picks and Prediction for Sunday September 21 2025

By: Eddie Kline Published 09/21/2025, 12:50 AM ET

Yankees Preview

The Sunday MLB schedule will get underway with a matinee between the New York Yankees and the Baltimore Orioles from Camden Yards. Be ready for the baseball season with all of our MLB predictions. The Yankees (87-68) have won seven of their last 11 games and are sitting atop the AL Wild Card standings. Last night, Giancarlo Stanton crushed a three-run blast and Aaron Judge added a solo shot to lead New York to a 6-1 road victory against Baltimore.

Rookie right-hander Cam Schlittler (3-3 3.41 ERA) will make his 13th career major league start for the Yankees. Last time out, Schlittler (4.2 IP) issued five walks and gave up four runs during a 10-9 road victory against Minnesota.

Orioles Preview

The Baltimore Orioles are three games below .500 at home and have been eliminated from postseason contention. During Saturday’s home loss, Baltimore batters managed just four hits and were retired by strikes 11 times. SP Tomoyuki Sugano (10-9) gave up four runs in three innings and took the loss for the Orioles, who fell to 73-82 overall.

The Orioles will counter with twenty-nine year old righty Kyle Bradish (1-1 2.45 ERA) in the series finale. In his last start, Bradish (5 IP) allowed one run and struck out nine batters during a 4-1 road victory against Chicago.

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Yankees vs Orioles Pick

Baltimore C Adley Rutschman (oblique) is on a rehab assignment with Triple-A Norfolk and hopes to return to the lineup this week. Through 155 games, New York ranks 1st in OPS and 1st in runs scored. For the season, Baltimore ranks 21st in OPS and 22nd in runs scored. Take the Orioles to win at home. Final Score Prediction, Baltimore Orioles win 5-3.

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