Baltimore Orioles vs St. Louis Cardinals Picks, Prediction, Odds, and Line Movement for Wednesday August 26 2026
The Baltimore Orioles vs St. Louis Cardinals series continues Wednesday night at Busch Stadium, with Baltimore looking to build on a dominant series-opening win as St. Louis tries to snap a four-game skid. For more angles across the league, check out these MLB predictions before first pitch. The Orioles enter at 64-68, while St. Louis sits at 66-67 and has now dropped four straight games.
TLDR: Quick Picks and Prediction
- Moneyline Pick: Baltimore Orioles (-104)
- Total Pick: Under 8.5 (-117)
- Projected Final Score: Orioles 4, Cardinals 3
Odds and Line Movement
Current Odds: Orioles vs Cardinals
| Date | Baltimore | St. Louis | Public ($, #) |
|---|---|---|---|
| 08/26 | -104 | -103 | STL 67%, 53% |
Line Movement - Moneyline
| Date | Baltimore | St. Louis | Public ($, #) |
|---|---|---|---|
| 08/26 | -104 | -103 | STL 67%, 53% |
| 08/26 | -110 | -109 | STL 66%, 53% |
| 08/26 | -111 | -109 | STL 66%, 53% |
| 08/26 | -113 | -107 | STL 67%, 54% |
| 08/26 | -113 | -107 | STL 67%, 54% |
| 08/26 | -110 | -110 | STL 67%, 53% |
| 08/26 | -110 | -110 | STL 59%, 42% |
| 08/25 | -108 | -112 | STL 89%, 88% |
| 08/25 | -108 | -112 | — |
Line Movement - Total
| Date | Over | Under | Public ($, #) |
|---|---|---|---|
| 08/26 | 8o-114 | 8u-106 | O91%, U56% |
| 08/26 | 8o-116 | 8u-104 | O93%, NULL |
| 08/26 | 8o-113 | 8u-107 | O90%, NULL |
| 08/26 | 8o-116 | 8u-104 | O92%, O75% |
| 08/26 | 8o-113 | 8u-107 | U92%, U90% |
| 08/26 | 8o-115 | 8u-105 | U94%, U92% |
| 08/26 | 8o-108 | 8u-112 | — |
| 08/25 | 8o-112 | 8u-108 | — |
| 08/25 | 8o-108 | 8u-112 | — |
| 08/25 | 8o-105 | 8u-115 | — |
Key Matchups and Game Preview: Orioles vs Cardinals
Baltimore will send right-hander Kyle Bradish to the mound with a 7-12 record, 3.70 ERA and 1.38 WHIP across 138.2 innings. Bradish has allowed 131 hits while striking out 129 against 60 walks and has surrendered 15 home runs, giving Baltimore a reasonably dependable starter despite his losing record. St. Louis counters with Michael McGreevy, who enters 5-9 with a 3.54 ERA and 1.21 WHIP through 137.1 innings. McGreevy has allowed 130 hits, struck out 95 and walked only 36, and his strong control gives the Cardinals a slight edge in baserunner prevention.
Baltimore has been the more productive power team, hitting 161 home runs compared with 138 for St. Louis, while the Orioles are batting .236 with a .318 OBP and .398 slugging percentage. Pete Alonso has been the centerpiece of Baltimore's lineup with 31 home runs, 89 RBI and a .276 average, along with a .364 OBP and .512 slugging percentage. St. Louis is batting .241 with a .316 OBP and .382 slugging percentage, with Alec Burleson leading the club at .291 and Jordan Walker supplying 27 home runs and 96 RBI while batting .287.
McGreevy owns the better ERA and WHIP, but Baltimore's offensive ceiling is clearly higher, and Tuesday's 13-run outburst showed how much more dangerous the Orioles can be when their power bats are producing.
Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Subscribe Now
BAL vs STL Betting Trends
Public money has leaned toward St. Louis throughout the buildup, drawing between 59% and 67% of bets and up to 54% of money at various points, though Monday's total saw as much as 89% of bets and 88% of money on the Cardinals. Total betting has been mixed, with the Over pulling as much as 93% of bets earlier Wednesday before the Under gained steam, reaching 94% of bets and 92% of money closer to first pitch.
BAL vs STL Injuries and Things To Know
Injuries could have a meaningful impact on both sides. Baltimore has Tyler O'Neill listed day-to-day, while Blaze Alexander, Felix Bautista, Ryan Helsley and Ryan Mountcastle remain unavailable, weakening both the lineup and bullpen. St. Louis is without Masyn Winn and Everson Pereira, while Andre Pallante, Hunter Dobbins and Max Rajcic are sidelined on the pitching staff.
Baltimore vs St. Louis Side and Over/Under Picks
- Side Pick: Baltimore Orioles Moneyline (-104)
- Total Pick: Under 8.5 (-117)
The market has this matchup essentially priced as a toss-up, with Baltimore around -104 and St. Louis -103, while the total is set at 8.5. With both starters carrying ERAs below 4.00 and neither offense posting an especially strong season-long slugging percentage, the Under also offers value after the high-scoring opener.
Orioles vs Cardinals Final Score Prediction
With Baltimore's offensive ceiling proving higher and Bradish capable of keeping the Orioles competitive on the mound, look for Baltimore to edge out a tighter, lower-scoring game than Monday's opener.
- Projected Final Score: Orioles 4, Cardinals 3
How to Wager on Baltimore vs St. Louis
Bettors looking to wager on this Orioles vs Cardinals matchup can shop lines across multiple sportsbooks to find the best number on Baltimore's moneyline or the Under 8.5 total. For additional tools and resources to help sharpen your betting approach, check out these AI picks, or dig into specific platform breakdowns like this Dimers review and this Oddible review for more ways to build out your betting strategy on this matchup and beyond.
Never Tried Picks and Parlays? Now Is Your Chance
- Get your first daily picks package for ONLY $1 using coupon code BUCK
- If the pick loses, we credit your account with 3 Flex Picks
- If the pick wins, we still give you 1 Flex Pick on the house
- Win or lose, you walk away ahead. One dollar. No catch.
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
New Users – Get $350 in Bonus Bets when you wager $5 for 7 days
New DraftKings Customer Offer: SPEND $5, GET $200 IN BONUSES
