Boston Red Sox vs Athletics Picks and Prediction for Wednesday September 10 2025

By: Eddie Kline Published 09/10/2025, 01:16 AM ET

Red Sox Preview

Sutter Health Park will play host to a Wednesday afternoon MLB clash between the Boston Red Sox and the Athletics. Be ready for the baseball season with all of our MLB predictions. The Red Sox (81-65) have split their first 74 road games and are sitting in second place in the AL Wild Card standings. Last night, Romy Gonzalez and Rob Refsnyder each homered to lead Boston to a 6-0 road victory against the Athletics.

Rookie left-hander Payton Tolle (0-1 7.56 ERA) will make his third career major league start for the Red Sox. Last time out, Tolle lasted just three innings and surrendered five runs during a 10-5 road loss against Arizona.

Athletics Preview

The Athletics have dropped eight of their previous 11 games and are trapped in the AL West Division cellar. During Tuesday’s home loss, the Athletics went 1-for-10 with runners in scoring position and left 11 men on base. SP Jeffrey Springs (10-11) was roughed up for five runs across five frames and took the loss for the Athletics (66-80), who fell to 29-42 at home.

Twenty-four year old righty Mason Barnett (1-1 9.00 ERA) will make his third career major league start for the Athletics. In his last start, Barnett (5 IP) gave up three runs and fanned eight batters during a 10-4 road triumph against Los Angeles.

Subscribe Now

I authorize Picks And Parlays to send me promotional emails

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Terms & Conditions

Red Sox vs Athletics Pick

Boston OF Roman Anthony has landed on the 10-day injured list with an oblique strain and could miss the next 4-6 weeks. Through 146 games, Boston ranks 8th in OPS and 4th in runs scored. For the season, the Athletics rank 6th in OPS and 12th in runs scored. Take the Red Sox to win on the road. Final Score Prediction, Boston Red Sox win 6-4.

Never Tried Picks and Parlays? Now Is Your Chance

Get your first daily picks package for ONLY $1 using coupon code BUCK
If the pick loses, we credit your account with 3 Flex Picks
If the pick wins, we still give you 1 Flex Pick on the house
Win or lose, you walk away ahead. One dollar. No catch.

Min. Deposit $5

Cashable No

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.

Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)

Cashable No

Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelplineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-HOPENY or text HOPENY (467369) (NY). 21+ (18+ DC, IA, KY, WV) only. New users only or text HOPENY (467369) (NY). Casino, First online real money wager only. $5 first deposit required. Min $5 wager required for 5 consecutive days. Bonus issued as non-withdrawable Bet Reset tokens. Refund from token issued as nonwithdrawable bonus bet that expire 7 days after receipt. Max refund $200 per day. Restrictions apply, including token expiration. See full terms at fanduel.com/sportsbook. Call 1-877-770-7867 (LA).

Min. Deposit $5

Odds Requirements -500

Cashable No

GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 7/19/26 at 11:59 PM ET. Sponsored by DK.