Boston Red Sox vs Tampa Bay Rays Picks and Predictions for Friday, September 19, 2025

By: David Anicetti Published 09/19/2025, 12:05 AM ET
Use Code PPWC

The Boston Red Sox visit the Tampa Bay Rays on Friday at George M. Steinbrenner Field. First pitch is scheduled for 7:35 PM ET on MLB.TV. Boston is second in the American League East and comes off a 5–4 win in extra innings, while Tampa Bay is fourth in the AL East after beating Toronto 2–1. Boston currently holds the third and final AL wild-card spot, and Tampa Bay is on the verge of being eliminated from playoff contention. Win big with our MLB predictions.

Boston Red Sox Preview

Boston sits at 83–69 with a 37–38 road record. The Red Sox have gone 2–3 in the last five games, splitting a series with Oakland and dropping two of three against the Yankees. Trevor Story has led the way with 24 homers, 92 RBI, and a .266 average. Jarren Duran adds steady contact with a .262 average and a .337 on-base percentage, while Alex Bregman has chipped in with 17 home runs in 106 games.

The pitching staff holds a 3.73 ERA and 1.29 WHIP, which has been one of the strengths of Boston all season. With no confirmed starter listed, Boston may turn to its bullpen to open the game and rest its starting rotation another day. The Red Sox have received strong performances from the pen of late.

Tampa Bay Rays Preview

Tampa Bay is 74–78 overall and 39–38 at home. The Rays are 2–3 across the last five, but won a close game against division-leading Toronto in the most recent game. The offense runs through Junior Caminero, who has 44 home runs and 108 RBI, and Yandy DΓ­az, who leads the team with a .299 batting average and 167 hits. Jonathan Aranda has also been a steady presence with a .316 average and .394 on-base percentage.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Drew Rasmussen is set to start. He has a 10–5 record with a 2.74 ERA and a 1.00 WHIP across 144.2 innings. With 122 strikeouts against only 34 walks, Rasmussen has been reliable and gives Tampa Bay a clear pitching edge. Rasmussen, with his low WHIP (1.00), has kept runners off base and stayed away from long, high-scoring innings.

Boston Red Sox vs Tampa Bay Rays Prediction

The Rays have a strong starter in Rasmussen and a lineup with both power and contact options. Boston’s bats are capable of putting up big numbers, but with Rasmussen on the mound, the edge leans toward Tampa Bay at home. Final Score Prediction: Tampa Bay Rays win 5-4.

Never Tried Picks and Parlays? Now Is Your Chance

  • Get your first daily picks package for ONLY $1 using coupon code BUCK
  • If the pick loses, we credit your account with 3 Flex Picks
  • If the pick wins, we still give you 1 Flex Pick on the house
  • Win or lose, you walk away ahead. One dollar. No catch.
BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $200 in Bonuses Instantly!

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Odds Requirements -500
Cashable No
Video: World Cup: Mexico vs England BEST Bets & Predictions | July 5, 2026
World Cup: Mexico vs England BEST Bets & Predictions | July 5, 2026
Video: Brazil vs Norway: The Bet You AREN'T Thinking Of! | BEST World Cup Predictions | July 5, 2026
Brazil vs Norway: The Bet You AREN'T Thinking Of! | BEST World Cup Predictions | July 5, 2026

Best Picks

  • Tampa Bay Rays
  • Tampa Bay Rays first five
logo

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright Β© 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.