Chicago Cubs vs Arizona Diamondbacks Picks, Prediction, Odds, and Line Movement for Tuesday August 25 2026
My Cubs vs Diamondbacks picks for Tuesday night favor Chicago, a team that just blanked Arizona 7-0 and now sends its best pitcher of the season back to the mound. For more plays across the league tonight, check out my MLB picks.
TLDR: Quick Picks and Prediction
- Side Pick: Chicago Cubs -112 moneyline
- Total Pick: Under 8.5
- Projected Final Score: Cubs 4, Diamondbacks 3
Odds and Line Movement
Chicago's moneyline has held in a tight range all week, opening around -111 on Sunday and Monday and settling at -112 by Tuesday morning, while Arizona has moved from -109 out to -108 over the same stretch. Public money has been heavily on the Cubs throughout, reaching as high as 94% of dollars wagered. The total opened near 8 runs on Monday before moving up to 8.5, with the Over priced as favorable as -101 and the Under moving out to -119 in the most recent readings, and the public has leaned Over as high as 95% in the latest reading.
Current Odds
| Team | Moneyline | Total |
|---|---|---|
| Chicago Cubs | -112 | Over 8.5 (-101) |
| Arizona Diamondbacks | -108 | Under 8.25 (-119) |
Line Movement - Moneyline
| Date | Chi. Cubs | Arizona | Public ($, #) |
|---|---|---|---|
| 08/25 | -112 | -108 | CHC 94%, 78% |
| 08/25 | -112 | -108 | CHC 92%, 73% |
| 08/25 | -112 | -108 | CHC 93%, 82% |
| 08/25 | -112 | -108 | CHC 93%, 82% |
| 08/24 | -114 | -106 | -- |
| 08/24 | -114 | -106 | -- |
| 08/24 | -112 | -108 | -- |
| 08/24 | -112 | -108 | -- |
| 08/24 | -110 | -110 | -- |
| 08/24 | -111 | -109 | -- |
Line Movement - Total
| Date | Over | Under | Public ($, #) |
|---|---|---|---|
| 08/25 | 8.5 (-101) | 8.25 (-119) | O95%, NULL |
| 08/25 | 8.5 (-102) | 8.25 (-118) | O88%, NULL |
| 08/24 | 8.5 (-105) | 8.25 (-114) | O92%, O91% |
| 08/24 | 8.5 (-102) | 8.25 (-118) | -- |
| 08/24 | 8 (-115) | 8 (-104) | -- |
| 08/24 | 8 (-114) | 8 (-106) | -- |
| 08/24 | 8 (-110) | 8 (-110) | -- |
Cubs vs Diamondbacks Key Matchups and Game Preview
Chicago
The Cubs are 76-56 and have won two straight games, including a 7-0 shutout in the series opener against Arizona. Clay Holmes gets the start and has been outstanding across 68.2 innings, posting a 5-6 record with a 2.49 ERA and 1.11 WHIP while allowing only 53 hits and four home runs. Chicago is hitting .250 as a team with a .339 on-base percentage, .424 slugging percentage, 176 home runs and 691 runs, giving the Cubs a clear offensive edge over Arizona. Pete Crow-Armstrong has been the driving force for Chicago, hitting .278 with 33 home runs, 83 RBIs and a .554 slugging percentage, providing both power and athleticism near the top of the lineup. The Cubs have injuries of their own, including Matt Shaw and multiple pitchers, but the lineup remains considerably healthier and more productive overall than Arizona's.
Diamondbacks
Arizona is 69-63 and looking to bounce back after being shut out in the series opener. Brandon Pfaadt takes the mound for the Diamondbacks at 7-1 with a 3.39 ERA and 1.14 WHIP over 98.1 innings, and he has issued only 24 walks, though Chicago's deeper offense presents a difficult matchup. Arizona is hitting .244 as a team with a .317 on-base percentage, .399 slugging percentage, 129 home runs and 598 runs. Nolan Arenado leads the way with 21 home runs and 65 RBIs, while Gabriel Moreno paces the club with a .303 average. Arizona is dealing with a major absence in Ketel Marte, who remains on the injured list with knee inflammation after hitting 21 home runs with 67 RBIs, removing one of the club's most dangerous bats from the middle of the order. Lourdes Gurriel Jr. is also working his way back from the injured list, further testing Arizona's offensive depth.
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Betting Trends: CHC and ARI
- Chicago has won two straight games, including a 7-0 shutout in the series opener.
- Arizona is looking to bounce back after being shut out on Monday.
- Public money has been heavily on the Cubs moneyline throughout the week, reaching as high as 94% of dollars wagered.
- The total has moved up from around 8 runs to 8.5 as the series has progressed.
- Clay Holmes has allowed only four home runs across 68.2 innings this season.
Key Injuries and Things To Know: CHC and ARI
- Chicago's Matt Shaw is dealing with an injury, along with multiple pitchers.
- Arizona's Ketel Marte remains on the injured list with knee inflammation.
- Arizona's Lourdes Gurriel Jr. is working his way back from the injured list.
Cubs vs Diamondbacks Side and Over/Under Picks
- Side Pick: Chicago Cubs -112 moneyline
- Total Pick: Under 8.5
Final Score Prediction
Holmes carries the stronger run-prevention numbers, Chicago owns the more dangerous offense, and Arizona is missing Marte from the middle of its lineup, giving the Cubs the clearer path to victory. Pfaadt should still keep the game competitive, which makes the moneyline preferable to laying 1.5 runs, and I expect this game to stay under the total.
- Projected Final Score: Cubs 4, Diamondbacks 3
How to Wager on Cubs vs Diamondbacks
Bettors looking to back Chicago on the moneyline or ride the Under 8.5 tonight have several ways to shop for the best number before first pitch. For a broader look at data-driven picks across the slate, check out my AI picks hub. If you want a deeper dive into specific model-based tools, my Dimers review and Oddible review break down how each platform grades this type of matchup and where they see the most value on Chicago versus Arizona.
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