Chicago Cubs vs Cincinnati Reds Picks and Prediction for Sunday September 20 2026

By: Eddie Kline Published 09/20/2026, 03:45 AM ET

Cubs Preview

The Great American Ball Park will play host to a Sunday afternoon MLB clash between the Chicago Cubs and the Cincinnati Reds. Be ready for the baseball season with all of our MLB predictions. The Cubs (86-69) have split their previous ten games and are clinging to a half-game lead over San Diego for the top spot in the National League Wild Card standings. Last night, Dansby Swanson and Michael Busch each homered to lead Chicago to a 5-2 road victory against Cincinnati.

Thirty-one year old southpaw David Peterson (8-8 5.11 ERA) will take the mound for the Cubs in this matchup. In his last start, Peterson (6 IP) allowed one run and retired seven batters by strikes during a 7-3 home victory versus Atlanta.ย 

Reds Preview

The Cincinnati Reds have dropped seven of their previous ten games and have been eliminated from postseason contention. During Saturdayโ€™s home loss, Cincinnati evened the score in the fifth inning on a Keโ€™Bryan Hayes RBI single. SP Nick Lodolo (3-6) gave up three runs in seven innings and was the hard luck loser for the Reds (72-83), who fell to 38-42 at home.ย 

Cincinnati skipper Terry Francona will give the nod to twenty-four year old righty Rhett Lowder (6-11 5.79 ERA) in the series finale. The Reds have dropped Lowderโ€™s previous three outings and he has surrendered 17 runs (16 ER) across his last 12 plus frames.ย 

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Cubs vs Reds Pick

Cincinnati 1B Spencer Steer (wrist) was transferred to the 60-day injured list and will be ready for spring training. Through 155 games, Chicago ranks 1st in OPS and 1st in runs scored. For the season, Cincinnati ranks 23rd in OPS and 26th in runs scored. Take the Cubs to win on the road. Final Score Prediction, Chicago Cubs win 6-3.ย 

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