Chicago Cubs vs Cincinnati Reds Picks and Prediction for Thursday September 18 2025
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Cubs vs Reds Game Information
The Chicago Cubs stay on the road Thursday for game one of a four-game series in Cincinnati against the Cincinnati Reds at Great American Ballpark at 7:15 PM. Chicago has 88 wins on the year and clinched a playoff spot with its victory on Wednesday. The Cincinnati Reds come into Wednesday hovering at .500 on the year, having dropped three of the last five overall. Stay in the action with our MLB Picks.
Cubs Preview
Nico Hoerner leads Chicago this season with a .303 batting average. Michael Busch has supplied the power for the Chicago lineup with 29 home runs this season. Seiya Suzuki leads Chicago this season with 91 RBI's and has posted a .243 batting average. As a unit this season, Chicago has a .250 batting average, having scored 735 runs on 1281 hits.
Reds Preview
Gavin Lux has carried the Cincinnati offense this season, leading the team with a .267 batting average. Elly De La Cruz Leeds inside of this season with 19 home runs and 82 RBI's. As a team, Cincinnati has a .245 batting average, having scored 676 runs and 1248 hits. The Cincinnati pitching has been mediocre this season, with a 3.99 team ERA.
Cubs vs Reds Pitching Matchup
Colin Rea will take the mound Thursday for Chicago. On the season, Rea is 10-6 overall with a 4.23 ERA across 146.2 innings of work. Hunter Greene will take the mound for Cincinnati, having compiled six wins and four losses and a 3.01 ERA in just under 93 innings this season.
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Cubs vs Reds Pick
The Reds are currently 2.5 games back of the final wild card spot and will continue to compete for the playoffs. Chicago is in the playoffs and has nothing left to play for. Look for Cincinnati to do the work Thursday night at home on both sides of the plate, leading to the victory.
Pick: Cincinnati Reds
Secondary: Over
Lean: Elly De La Cruz Over .5 RBI
Final Score Prediction: Cincinnati Reds win 6-4.
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