Chicago Cubs vs Cincinnati Reds Picks and Predictions for Saturday, September 19th, 2026

Chicago Cubs vs Cincinnati Reds Game Information

The Chicago Cubs continue their weekend series Saturday at 6:40 PM at Great American Ball Park against the Cincinnati Reds. Chicago enters game 2 of this series on Saturday as the second-best team in the National League Central, battling the Philadelphia Phillies for the top NL Wild Card spot. The Cincinnati Reds stay home on Saturday well below .500 as they have struggled all year. For more MLB news, see our MLB Picks.

Chicago Cubs Preview

Chicago has one of baseball's most productive offenses, batting .252 with 817 runs scored on 1,320 hits. The Cubs own a .340 OBP and a .431 team slugging percentage. Their pitching staff has registered a 4.19 ERA. Pete Crow-Armstrong has been the top offensive weapon, leading Chicago with a .282 batting average, 44 home runs, and 105 RBIs as he pursues the National League MVP.

Cincinnati Reds Preview

Cincinnati comes into the matchup batting .230 after scoring 633 runs on 1,168 hits. The Reds have a .307 OBP and a .396 slugging percentage, while their pitching staff has struggled to a 4.85 ERA. Elly De La Cruz leads Cincinnati with a .284 batting average. Sal Stewart has a .271 batting average this year and leads the Cincinnati offense with 32 home runs and 109 RBIS.

Chicago Cubs vs Cincinnati Reds Pitching Matchup

Matthew Boyd will start for the Cubs. Boyd is 8-5 with a 4.16 ERA this season. Nick Lodolo will take the mound for Cincinnati, entering Saturday with a 3-5 record and a 5.12 ERA.

Chicago Cubs vs Cincinnati Reds Pick

Chicago has a major offensive advantage and should capitalize on Lodolo’s struggles. The Cubs have scored nearly 200 more runs than Cincinnati and possess considerably more power throughout their lineup. Expect Chicago to score early and pull away against the Reds’ pitching staff as the Cubs continue their push for a playoff spot on Saturday.

• Pick: Chicago Cubs
• Secondary: Over
• Lean: Pete Crow-Armstrong Over 1.5 Bases

Final Score Prediction: Chicago Cubs 7-4

Game Written Before Completion of the Game on Friday

Never Tried Picks and Parlays? Now Is Your Chance

• Get your first daily picks package for ONLY $1 using coupon code BUCK
• If the pick loses, we credit your account with 3 Flex Picks
• If the pick wins, we still give you 1 Flex Pick on the house
• Win or lose, you walk away ahead. One dollar. No catch.

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code

Claim Bonus

Signup Promo Recommended BetMGM Sport Bonus

Min. Deposit $5

Cashable No

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, Massachusetts, New York, Ontario, or Puerto Rico.

New Users – Get $350 in Bonus Bets when you wager $5 for 7 days

Show Bonus Code

Claim Bonus

Signup Promo Hot Offer FanDuel Sportsbook Bonus

Requirement New Users – Get $350 in Bonus Bets when you wager $5 for 7 days ($50 Bonus Bets per day)

Cashable No

Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelpLineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY). 21+ (18+ D.C., KY, WY) and present in select states (for KS, in affiliation with Kansas Star Casino). First online real money wager only. Min $5 wager required for 7 consecutive days.$5 first deposit required. Bonus issued as nonwithdrawable bonus bets which expire 7 days after receipt. Restrictions apply. See terms at sportsbook.fanduel.com. Call 1-877-770-7867 (LA). ™/© 2026 MLB

New DraftKings Customer: SPEND $5, GET $200 IN BONUSES

Show Bonus Code

Claim Bonus

Signup Promo Hot Offer DraftKings Sport Bonus

Min. Deposit $5

Requirement New DraftKings Customer Offer: SPEND $5, GET $200 IN BONUSES ($50 in Bonus Bets every 7 days for 21 days)*

Cashable No

To be eligible for DraftKings Sportsbook and the Promotion, you must be physically located in AR, AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA (select parishes), MA, MD, ME, MI, MO, NC, NJ, NH, NY, OH, OR, PA, PR (residents only), TN, VA, VT, WY, WV, CA-ONT or CA-AB (each an “Eligible Jurisdiction” or, collectively, the “Eligible Jurisdictions”). Must be 21+ years of age or older (18+ if in DC/NH/PR/WY/CA-AB) (19+ in CA-ONT). GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA) Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets. Stake removed from payout. Reward issued as $50 in Bonus Bets every 7 days via click-to-claim for 21 days. Bonus Bets and click-to-claims expire 7 days (168hrs) after issuance. Terms: Promos | DraftKings Sportsbook . Ends 9/20/26 at 11:59 PM ET. Sponsored by DK.

Toronto Blue Jays vs Texas Rangers Picks and Predictions for Saturday, September 19th, 2026

Toronto Blue Jays vs Texas Rangers Game Information The Toronto Blue Jays will be on the road Saturday for a 7:05 PM matchup at Globe...

Atlanta Braves vs Houston Astros Picks and Predictions for Saturday, September 19th, 2026

Atlanta Braves vs Houston Astros Game Information The Atlanta Braves will play the Houston Astros Saturday at 7:10 PM inside Daikin Park. Atlanta enters the...

Kansas City Royals vs Pittsburgh Pirates Picks and Predictions for Saturday, September 19th, 2026

Kansas City Royals vs Pittsburgh Pirates Game Information The Kansas City Royals will face the Pittsburgh Pirates Saturday at 6:40 PM inside PNC Park. Kansas...

Chicago Cubs vs Cincinnati Reds Picks and Predictions for Saturday, September 19th, 2026

Chicago Cubs vs Cincinnati Reds Game Information The Chicago Cubs continue their weekend series Saturday at 6:40 PM at Great American Ball Park against the...

Detroit Tigers vs Chicago White Sox Picks and Predictions for Saturday, September 19th, 2026

Detroit Tigers vs Chicago White Sox Game Information The Detroit Tigers stay on the road Saturday for a 7:10 PM contest against the Chicago White...

Seattle Mariners vs Colorado Rockies Picks and Prediction for Saturday, September 19, 2026

The Seattle Mariners visit the Colorado Rockies on Saturday at Coors Field, with the opening pitch scheduled for 8:10 PM ET on MLB.TV. Seattle is...

Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions

Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview