Chicago Cubs vs Miami Marlins Picks and Prediction for Saturday September 5 2026

By: Eddie Kline Published 09/05/2026, 01:05 AM ET

Cubs Preview

The Saturday MLB schedule will get underway with a matinee between the Chicago Cubs and the Miami Marlins from LoanDepot Park. Be ready for the baseball season with all of our MLB predictions. The Cubs (80-62) have won 39 of their first 70 road tilts and hold a half-game lead over Philadelphia for the top spot in the National League Wild Card standings. Last night, 1B Michael Busch homered and scored twice to spark Chicago to a 6-1 road victory against Miami.Β 

Thirty-three year old righty Clay Holmes (6-6 2.09 ERA) will take the mound for the Cubs in this matchup. In his last start, Holmes fired six shutout frames and fanned eight batters during a dominant 17-3 home victory versus Milwaukee. Through 81 plus innings, Holmes has allowed just four home runs.Β 

Marlins Preview

The Miami Marlins have dropped seven of their previous 11 games and are 3.5 games back in the race for the final National League Wild Card spot. During Friday’s home loss, Griffin Conine collected two of Miami’s four hits and scored their only run. SP Janson Junk (6-9) gave up one run in five innings and was the hard luck loser for the Marlins (71-71), who fell to 42-28 at home.Β 

Twenty-seven year old righty Ryan Gusto (1-3 3.86 ERA) will make his 15th start of the year for the Marlins. Last time out, Guston (4.1 IP) allowed four hits and one run during a 6-3 road loss against Washington.Β Β 

Sign Up Get $30 Premium Picks Credit + Exclusive Offers

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Cubs vs Marlins Pick

Chicago SP Justin Steele (elbow) made a rehab appearance for Triple-A Iowa on Wednesday and could be used as a reliever down when he returns. Through 142 games, Chicago ranks 1st in OPS and 1st in runs scored. For the season, Miami ranks 11th in OPS and 19th in runs scored. Take the over. Final Score Prediction, Chicago Cubs win 7-4.Β 

Never Tried Picks and Parlays? Now Is Your Chance

  • Get your first daily picks package for ONLY $1 using coupon code BUCK
  • If the pick loses, we credit your account with 3 Flex Picks
  • If the pick wins, we still give you 1 Flex Pick on the house
  • Win or lose, you walk away ahead. One dollar. No catch.
BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Get $350 in Bonus Bets when you wager $5 for 7 days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Get $350 in Bonus Bets when you wager $5 for 7 days ($50 Bonus Bets per day)
Cashable No
DraftKings Sport

New DraftKings Customer: SPEND $5, GET $200 IN BONUSES

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Requirement New DraftKings Customer Offer: SPEND $5, GET $200 IN BONUSES ($50 in Bonus Bets every 7 days for 21 days)*
Cashable No
Video: Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions
Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions
Video: Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview
Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview
logo

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright Β© 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.