Chicago Cubs vs Milwaukee Brewers Picks and Prediction for Saturday October 11 2025

By: Eddie Kline Published 10/11/2025, 12:00 AM ET

Cubs Preview

A spot in the National League Championship Series will be up for grabs on Saturday, when the Chicago Cubs battle the Milwaukee Brewers from American Family Field. Be ready for the baseball season with all of our MLB predictions. The fourth-seeded Cubs (2-2) dropped the first two games of this series on the road and are looking to advance to the league championship series for the first time since 2017. In Game Four, Ian Happ’s three-run blast in the opening frame was all the offense Chicago would need during a 6-0 home victory.

Chicago manager Craig Counsell has not named a starting pitcher for this game. The Cubs rank fifth during the playoffs with a 2.95 ERA. Starters Colin Rea (3.95 ERA), Shota Imanaga (3.73 ERA), and Jameson Taillon (3.68 ERA) will all be available in this winner-take-all spot.

Brewers Preview

The Milwaukee Brewers have reached the postseason in seven of the previous eight years and are in search of their first World Series title in franchise history. During Thursday’s road loss, Milwaukee batters were limited to three hits and struck out eight times. SP Freddy Peralta (1-1) gave up three runs in four innings and took the loss for the Brewers.

Milwaukee skipper Pat Murphy has not announced a starting pitcher for this contest. The Brewers ranked second during the regular season with a 3.58 ERA). Rookie SP Jacob Misiorowski fired three shutout frames in Game Two and figures to be relied on heavily in this all hands on deck approach.

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Cubs vs Brewers Pick

Milwaukee SP Brandon Woodruff is dealing with a lat injury and will not pitch in this series. Through 162 games, Chicago ranks 7th in OPS and 5th in runs scored. For the season, Milwaukee ranks 11th in OPS and 3rd in runs scored. Take the Brewers to win at home. Final Score Prediction, Milwaukee Brewers win 4-2.

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