Chicago Cubs vs Pittsburgh Pirates Picks and Predictions for Saturday, July 25, 2026

By: Cameron Ross Published 07/25/2026, 12:40 AM ET

The Chicago Cubs are on the road Saturday night with a 6:40 PM matchup inside PNC Park in Pittsburgh against the Pittsburgh Pirates. Chicago is 13 games above .500 this season, currently 6 games back of the National League Central lead, having won 3 of the last 5 following the win in Game 1 of this set. The Pittsburgh Pirates stay home Saturday, 2 games above .500, but they have dropped 3 of the last 4, including 2 in a row. Stay in the news with our MLB Picks.

Cubs Preview

The Chicago Cubs have a .245 batting average this season, scoring 520 runs on 853 hits. Chicago has a .338 OBP and a .413 team slugging percentage. The Cubs pitching has been inconsistent, however, with a 4.27 team ERA this year. Pete Crow-Armstrong leads the Chicago offense with a .285 batting average and 22 home runs, while Dansby Swanson leads the team with 59 RBIs.

Pirates Preview

The Pittsburgh Pirates have a .261 batting average this season, scoring 543 runs on 933 hits. Pittsburgh has a .339 OBP and a .424 team slugging percentage. The Pirates pitching has struggled at times with a 4.26 team ERA this year. Nick Gonzales leads the Pirates offense with a .312 batting average. Brandon Lowe leads the team with 21 home runs and 65 RBIs.

Cubs vs Pirates Pitching Matchup

Shota Imanaga will take the mound Saturday for the Cubs, looking to build off a dominant performance against Minnesota. Imanaga is 6-8 this year with a 3.91 ERA through 115 innings of work. Paul Skenes will counter for Pittsburgh, looking to continue his climb. Skenes is 9-8 with a 3.43 ERA through 115.1 innings of work.

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Cubs vs Pirates Pick

The Pirates have a better pitcher on the mound, but Chicago has the better offense and comes into this game playing better. Take the Cubs to continue their winning ways as they get it done Saturday in Pittsburgh in Game 2 of 3 against the Pirates.

  • Pick: Chicago Cubs
  • Secondary: Under
  • Lean: Pete Crow-Armstrong Over 1.5 Bases

Final Score Prediction: Chicago CubsΒ Β win 4-2.

Game Written Before completion of the game on Friday.

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