Chicago Cubs vs San Diego Padres Picks and Predictions for Monday, April 27, 2026
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Cubs vs Padres Game Information
The Chicago Cubs will be on the road Monday night for game 1 of 3 inside Petco Park in San Diego, CA, at 9:40 PM against the San Diego Padres. Chicago comes into Monday with 17 wins and 11 losses on the year, riding a 2-game skid following consecutive losses in Los Angeles. The San Diego Padres will be back home Monday night with 18 wins and 9 losses this season, having won 3 of the last 5 after a 5-run loss to Arizona in Mexico City. Stay in the news with our MLB Picks.
Cubs Preview
Offensively, Chicago has been solid this season with a .268 batting average, scoring 149 runs on 250 hits. The Chicago power has been loud this season as the Cubs have combined for 37 home runs and a .436 team slugging percentage. Chicago's pitching has been just as strong, with a 3.79 team ERA. Nico Hoerner leads the Chicago offense this season with a .307 batting average and 23 RBIs. Ian Happ has a .235 batting average along with a team-leading 7 home runs.
Padres Preview
Offensively, San Diego has been below average this season, with a .233 batting average. The Padres have scored only 116 runs on 200 hits. San Diego has a .310 OBP and a .373 team slugging percentage. San Diego's pitching has been the team's biggest strength, with a 3.63 team ERA, but it has allowed 20 runs over its last 2 losses. Xander Bogaerts leads the San Diego offense this season with a .278 batting average. Manny Machado has a .209 batting average along with a team-leading 4 home runs. Ramon Laureano has a .255 batting average and leads San Diego this season with 18 RBI's.
Cubs vs Padres Pitching Matchup
Matthew Boyd will take the mound Monday night for Chicago in Game 1 of this series. This year, Boyd is 1-1 overall with a 5.79 ERA across 14 innings of work. Randy Vasquez will take the mound for San Diego Monday night at home. Vasquez is undefeated this season with a 1.88 ERA across 28.2 innings of action.
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Cubs vs Padres Sox Pick
Both teams have had some success this season, as they come into this game well above .500. Look for San Diego, however, to do the job as they will have the better pitcher on the mound and their home fans behind them. Take the Padres on Monday night to get the win as they open this series against Chicago.
- Pick: San Diego Padres -105
- Secondary: Under 8
- Lean: Manny Machado Over 1.5 Bases
Final Score Prediction: San Diego Padres win 4-1.
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