Chicago White Sox vs Cleveland Guardians Picks and Predictions for Saturday, September 13, 2025
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White Sox vs Guardians Game Information
The Chicago White Sox play the second game of a three-game series on the road Saturday versus the Cleveland Guardians at Progressive Field with a 4:10 PM ET first pitch. Cleveland is 75–71 and 38–34 at home, while Chicago is 57–90 and 25–47 on the road. The starters are right-hander Davis Martin (6–9, 4.03 ERA, 1.28 WHIP) for the White Sox and left-hander Parker Messick (2–0, 1.93 ERA, 1.33 WHIP) for the Guardians. The baseball season is almost over, but that does not mean your winning ways have to be! Make sure you get our free MLB picks today for help finding the best picks!
Chicago White Sox Preview
Chicago’s game plan is to remain close behind pitcher Martin and hope for timely hits. Martin has pitched 127.1 innings with only 19 homers allowed, good enough if he stays ahead in counts and avoids issuing walks. The White Sox team ERA and WHIP are only average (4.22 ERA, 1.36 WHIP), but with Martin slightly better than average, a few key hits by the White Sox could produce enough to win.
Chicago has been led at the plate by Lenyn Sosa and Miguel Vargas. Sosa leads with a .265 average and 20 homers, and Kyle Teel has come on strong in the second half of the season, with a slash line of .290/.391/.440. Chicago’s .236 team average and .378 slugging percentage show the White Sox must put runners on base and hope for timely hitting..
Cleveland Guardians Preview
Cleveland has played better and has a better bullpen. The Guardians have won four of five and carry a 3.86 team ERA. The Guardians will rely on their starter to reach the sixth or seventh and hand it over to the bullpen. Despite not being a power-hitting team and producing many runs, Cleveland has had excellent performances from its bullpen when ahead and look for that again on Saturday.
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Steven Kwan’s 155 hits lead the Guardians, but the overall production of José Ramírez has taken the Guardians where they are today, fighting for an AL wildcard. Ramirez has a .285/.358/.507 line with 28 home runs and 77 RBI. Kyle Manzardo has shown power (26 homers), and different role players have stepped up when called upon by the manager and coaching staff.
Prediction Chicago White Sox vs Cleveland Guardians
The prediction leans toward the home team, Cleveland. The Guardians’ pitching and timely hitting with some power will be enough to overcome a below-average lineup for the White Sox. Chicago’s Martin can keep the game close, but Ramírez and Manzardo, with help from Kwan, will produce enough runs for the Guardians to win. Final Score Prediction: Cleveland Guardians win 6-3.
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