Chicago White Sox vs Milwaukee Brewers Picks and Prediction for Saturday March 28 2026
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The Chicago White Sox and Milwaukee Brewers meet at American Family Field in Milwaukee, Wisconsin on Saturday, March 28, 2026, with first pitch scheduled for 7:10 PM. The game will be carried on MLB.TV. The betting odds for this matchup list the White Sox at +163 on the moneyline and the Brewers at -199, while the total is set at 8 runs. On the run line, Chicago is +1.5 at -136 and Milwaukee is -1.5 at +113. Be sure to check out our free MLB picks for more analysis on today’s schedule.
Previous Game Recap & Box Score
The previous game between these teams was one-sided from the middle innings on, as Milwaukee rolled to a 14-2 win over Chicago. The White Sox struck first with a run in the opening inning, but the Brewers quickly answered with four runs in the second and never looked back. Milwaukee kept pressure on throughout the night, adding two more in the fourth, two in the fifth, three in the sixth, and three more in the seventh. By the end of the game, the Brewers had completely taken control and turned an early deficit into a dominant 12-run victory.
From the box score standpoint, Chicago managed just 2 runs on 4 hits and committed 1 error, while Milwaukee erupted for 14 runs on 12 hits without an error. The White Sox left 7 runners on base and went 0-for-5 with runners in scoring position, which made it difficult to build any sustained offense beyond the two solo home runs. Milwaukee also left 7 runners on base, but the Brewers were far more efficient in key spots, finishing 6-for-14 with runners in scoring position. That difference in situational hitting told the story of the game as Milwaukee consistently cashed in chances while Chicago could not.
The hitting summary for Chicago begins with Munetaka Murakami and Chase Meidroth, who accounted for both runs with solo home runs. Murakami finished with one hit, one RBI, two walks, and a .500 average with a .750 on-base percentage and 2.000 slugging percentage, while Meidroth had one hit, one RBI, and also drew two walks. Austin Hays and Luis Acuna added the other two hits for the White Sox, but the rest of the lineup struggled badly, and the club struck out 20 times. For Milwaukee, the offensive production came from all over the lineup. Jake Bauers had two hits, a home run, and three RBI, while William Contreras also drove in three runs. Sal Frelick homered and knocked in two, Joey Ortiz collected two hits and two RBI, Christian Yelich had two hits and an RBI, and Brice Turang added two hits. Milwaukee also drew 10 walks, which only added to the pressure it placed on Chicago pitching all night.
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On the mound, the White Sox had a rough evening from start to finish. Shane Smith took the loss after working 1.2 innings and allowing 4 runs, 3 of them earned, on 3 hits while walking 2 and striking out 2. Sean Newcomb followed and gave up 2 more runs in 2.1 innings. Tyler Gilbert allowed 2 runs and a home run in his inning of work, Jordan Hicks surrendered 3 runs while issuing 4 walks in just two-thirds of an inning, and J. Paez also allowed 3 runs and a home run in 1.1 innings. J. Leasure was the only Chicago pitcher to post a scoreless outing. As a staff, the White Sox gave up 14 runs, 13 earned, on 12 hits while walking 10 and striking out only 3. Milwaukee’s pitching performance was the opposite. J. Misiorowski earned the win by going 5.0 innings and allowing just 1 run on 2 hits while striking out 11 and walking 3. A. Ashby and G. Anderson each tossed a scoreless inning, D. Hall worked around traffic without allowing a run, and J. Woodford gave up the second White Sox run in the ninth. Altogether, the Brewers held Chicago to 4 hits, 2 runs, and 20 strikeouts.
The key takeaway is that Milwaukee looked sharper in every area of the game. The Brewers were better offensively, more patient at the plate, and overwhelmingly more effective on the mound. Chicago showed a little power with two solo shots, but outside of that there was very little offensive consistency, while Milwaukee’s lineup proved it can put together rallies throughout the order and sustain pressure over multiple innings.
Chicago White Sox – Road Form & Team Analysis
The White Sox enter this game at 0-1 overall and 0-1 on the road. Chicago recently lost to Milwaukee, recently lost to the Athletics, recently lost to Seattle, recently lost to Cincinnati, and recently lost to the Angels. That gives the White Sox five recent losses, and the latest result was easily the most lopsided of the group.
As a team, Chicago is batting .129 with 2 runs, 4 hits, and 2 home runs. The White Sox have produced a .250 on-base percentage and a .323 slugging percentage. On the mound, they carry a 14.63 ERA and a 2.75 WHIP, with 10 walks and 3 strikeouts, while opponents are batting .364 against them. Those numbers show a club that has had trouble both creating offense and preventing hard contact early on.
The biggest issue for the White Sox right now is that the offense has not been able to sustain anything beyond isolated moments. Murakami and Meidroth both went deep in the opener, but the team still managed only four total hits and struck out 20 times. That kind of swing-and-miss problem makes it hard to build innings, and the lack of success with runners in scoring position only added to the trouble. On top of that, the pitching staff put too many men on base with 10 walks and allowed Milwaukee to turn nearly every opening into a scoring chance.
Milwaukee Brewers – Home Field Breakdown
Milwaukee comes into this matchup with a 1-0 overall record and a 1-0 mark at home. The Brewers recently won over the White Sox, recently won over Cincinnati, recently won over Cincinnati again, recently lost to the Cubs, and recently won over San Diego. That stretch points to a club carrying strong form into the second game of this matchup, especially at home.
The Brewers are hitting .364 with 14 runs, 12 hits, and 2 home runs. They also own a .512 on-base percentage and a .606 slugging percentage. On the pitching side, Milwaukee has posted a 2.00 ERA and a 1.00 WHIP, with 5 walks and 20 strikeouts, while holding opponents to a .129 batting average. Those are excellent early numbers and line up closely with how dominant they looked in the opener.
The most impressive thing about Milwaukee’s profile is the balance. Jake Bauers drove in three runs with a home run, William Contreras drove in three more, and Sal Frelick added another homer with two RBI, but the production did not stop there. Christian Yelich, Joey Ortiz, Andrew Vaughn, D. Hamilton, and Garrett Mitchell all contributed to the scoring. The lineup also drew 10 walks, which shows patience as well as power. When that is paired with a pitching staff that just racked up 20 strikeouts and limited Chicago to four hits, Milwaukee clearly enters this game with the stronger overall edge.
Pitching Matchup Breakdown
This pitching matchup features Chicago right-hander Sean Burke, jersey number 59, against Milwaukee right-hander Chad Patrick, jersey number 39. Burke is listed at 6-foot-6 and 240 pounds, throws right-handed, and was born in Sutton, Massachusetts. In the 2025 season, Burke went 4-11 with a 4.29 ERA and a 1.45 WHIP across 134.1 innings. He recorded 133 strikeouts and 63 walks while allowing 132 hits and 64 earned runs. Opponents hit .253 against him with a .338 opponent on-base percentage and a .448 opponent slugging percentage. His career numbers show a 6-11 record with a 3.93 ERA and a 1.40 WHIP over 153.1 innings, with 155 strikeouts and 70 walks. Patrick is listed at 6-foot-1 and 217 pounds, throws right-handed, and was born in Crown Point, Indiana. In the 2025 season, Patrick went 3-8 with a 3.53 ERA and a 1.28 WHIP over 119.2 innings. He struck out 127 and walked 40 while allowing 113 hits and 47 earned runs. Opponents hit .248 against him with a .313 opponent on-base percentage and a .387 opponent slugging percentage. Based strictly on the provided data, Patrick enters with the lower ERA, lower WHIP, fewer hits allowed, and stronger overall run prevention profile, while Burke offers a solid strikeout total but comes in with more traffic allowed and a less efficient statistical line.
Chicago White Sox vs Milwaukee Brewers Pick
Chicago White Sox vs Milwaukee Brewers Spread / Moneyline Pick
The pick is the Milwaukee Brewers moneyline. Milwaukee already dominated this matchup 14-2 in the opener, and the Brewers enter this game with a major edge in both recent form and early team production. They are batting .364 with 14 runs and a .512 on-base percentage, while Chicago is batting .129 with only 2 runs and has lost five recent games in a row. On the mound, Milwaukee also owns the better early team ERA and WHIP, and Chad Patrick’s 2025 numbers compare favorably to Sean Burke’s across ERA, WHIP, hits allowed, and opponent production. When that is combined with the Brewers’ offensive explosion from the previous game, Milwaukee is the stronger side.
Chicago White Sox vs Milwaukee Brewers Total Pick
I like the over 8 in this matchup. The first game between these teams finished with 16 total runs, and Milwaukee showed it can generate offense in a lot of different ways with 14 runs on 12 hits, 2 home runs, and 10 walks. Chicago did not produce much overall, but the White Sox still managed two home runs even while struggling badly at the plate. Sean Burke allowed a 4.29 ERA and 1.45 WHIP in 2025, and the White Sox staff just gave up 14 runs in the opener, so there is enough data here for me to expect more scoring. With Milwaukee’s lineup swinging well and Chicago still capable of contributing some power, I like this game to finish over the posted number.
Final Score Prediction: Milwaukee Brewers win 7–3
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