Chicago White Sox vs Milwaukee Brewers Picks and Prediction for Thursday March 26 2026

By: Eddie Kline Published 03/26/2026, 01:25 AM ET

White Sox Preview

In Thursday afternoon MLB interleague action, the Chicago White Sox will travel to American Family Field to take on the Milwaukee Brewers. Be ready for the baseball season with all of our MLB predictions. Since their 2005 World Series title, the White Sox have missed the postseason 17 times and have not won a playoff series. Chicago SS Colson Montgomery crushed 21 home runs in his rookie season and headlines a lineup of up-and-coming young hitters.

Twenty-five year old righty Shane Smith (7-8 3.81 ERA) quietly put together a solid rookie season for the White Sox. Through 146 plus major league innings, Smith has retired 145 batters by strikes and owns a 1.20 WHIP.

Brewers Preview

The Milwaukee Brewers have qualified for the postseason in seven of their previous eight years, but have just one playoff series win to show for it. The Brewers continue to exceed their preseason expectations and have won three straight NL Central Division titles. In two years at the major league level, Milwaukee OF Jackson Chourio has hit 42 home runs and swiped 43 bags.

Despite throwing just 66 innings as a rookie, flame-throwing righty Jacob Misiorowski (5-3 4.36 ERA) was an All-Star. The talent of the twenty-three year old is undeniable and he could lead the majors in strikeouts at some point in his career. Last season, Misiorowski struck out 87 batters and surrendered eight long balls.

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White Sox vs Brewers Pick

Milwaukee OF Akil Baddoo (quadriceps) was placed on the 60-day injured list and is not eligible to make his season debut until June. In 2025, Chicago ranked 28th in OPS and 27th in runs scored. Last season, Milwaukee ranked 11th in OPS and 3rd in runs scored. There is some value on the underdog White Sox, but the stronger play is on the under. Final Score Prediction, Milwaukee Brewers win 4-2.

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