Chicago White Sox vs Minnesota Twins Picks and Predictions, for Monday, September 1, 2025

By: David Anicetti Updated 09/01/2025, 01:30 PM ET

The Chicago White Sox open a four-game series on the road Monday versus the Minnesota Twins. Chicago dropped to 48-88 following Saturday’s 5-3 loss to the New York Yankees. Chicago has lost each of the first three games of a four-game series versus New York and has lost five straight overall. The White Sox are 30.5 games behind first place in the American League Central and well off the pace for postseason contention. Be ready for all the potential MLB action this September with our free MLB Picks.

Lenya Sosa is batting .267 with 17 home runs, 60 RBI, and 115 hits to lead Chicago in each of the four categories. Miguel Vargas leads Chicago in on-base percentage at .315. Chicago is batting .234 with a .372 slugging percentage. On Monday, the Chicago White Sox will send Aaron Civale to the mound. The right-hander is 3-9 with a 5.26 ERA, 74 Ks, and 33 BBs.

The Minnesota Twins dropped to 61-74 following Saturday’s 12-3 loss to the San Diego Padres. Minnesota has lost five of the last seven. The Twins are struggling to score runs, sitting 25th in baseball in runs scored, and on the mound are a disappointing 23rd in ERA. Minnesota trails first-place Detroit in the American League Central by 17 games, and the Twins trail the third and final AL wild card spot by 10.5 games.

Byron Buxton is batting .270 with 28 home runs, 68 RBI, and 107 hits to lead Minnesota in each of the full categories. Ryan Jeffers is the leader in on-base percentage at .347. Minnesota is batting .238 with a .397 slugging percentage. Minnesota has not announced its starting pitcher for the opening game of a four-game series at home on Monday versus Chicago.

Chicago is 0-5 in its last 5
The OVER has cashed in 4 of the White Sox’s last 5
Minnesota is 4-11 in its last 15
The OVER has cashed in each of the Twins’ last 5

Twins vs White Sox Prediction

The Minnesota Twins will win at home on Monday when hosting the Chicago White Sox, but the play here is OVER. The OVER has cashed in four of Chicago's last five, each of Minnesota's last five, and four of Minnesota's last five played at home. Chicago starter Aaron Civale has been hit hard in four consecutive outings, allowing 21 runs on 26 hits across 19 innings. Final Score Prediction: Minnesota Twins win but our best play is OVER 8-4.

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