Chicago White Sox vs New York Yankees Picks and Predictions for Wednesday, September 24, 2025
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The Chicago White Sox visit the New York Yankees on Wednesday at Yankee Stadium. The first pitch is scheduled for 7:05 PM ET on YES. The White Sox are 58โ98, last in the AL Central, while the Yankees are 88โ68, second in the AL East. Chicago has lost four of five, while New York has won four of its last five. Chicago has been eliminated from postseason contention, while New York is two games behind first-place in the AL East and currently holds the first of three AL wildcards. Sweep a series with our MLB Picks.
Chicago White Sox Preview
The White Sox enter this matchup with another difficult stretch behind them, dropping two of three to San Diego. On the road, Chicago has been one of the leagueโs weakest teams with a 25โ50 mark. Lenyn Sosa has produced the most in the lineup, leading the club with a .259 average, 21 home runs, and 71 RBIs.
Beyond Sosa, the offense has struggled to find consistency, ranking near the bottom of the American League in runs scored. Andrew Benintendi has chipped in with 20 homers, while Luis Robert Jr. has 14, but Chicago has not generated steady run production. The White Sox have not announced a starting pitcher for Wednesdayโs game on the road against the Yankees.
New York Yankees Preview
The Yankees continue to surge in September, winning four of their last five games, including a series win in Baltimore. New York has been led by Aaron Judge, who is putting together another MVP-caliber year with 49 home runs, 105 RBIs, and a .326 batting average. Cody Bellinger and Jazz Chisholm Jr. provide plenty of power behind Judge, helping the Yankees reach 816 total runs this season.
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On the mound, New York will send Max Fried, who has delivered all season with an 18โ5 record, 2.92 ERA, and 182 strikeouts across 188.1 innings. Friedโs consistency each time out gives New York a major advantage, especially against a Chicago lineup that has struggled to score runs. The Yankees are 44-31 at home this season.
Chicago White Sox vs New York Yankees Prediction
New York holds advantages at the plate and on the mound in this matchup with Chicago. The Yankeesโ lineup and Friedโs ability to shut down hitters should be too much for a White Sox team that has struggled at the plate the entire season. Final Score Prediction: New York Yankees win 8-2.
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Best Picks
- New York Yankees -1.5 run line
- Over 8.5 runs
