Chicago White Sox vs Philadelphia Phillies Picks and Prediction for Friday June 5 2026

By: Eddie Kline Published 06/05/2026, 12:25 AM ET

White Sox Preview

In Friday night MLB interleague action, the Chicago White Sox will travel to Citizens Bank Park to take on the Philadelphia Phillies. Be ready for the baseball season with all of our MLB predictions. The White Sox (33-29) have won seven of their last ten games and trail AL Central Division leading Cleveland by two games. On Wednesday, rookie OF Sam Antonacci went 4-for-4 and scored a pair of runs to lead Chicago to an 8-0 road victory against Minnesota.

Thirty-one year old left-hander Anthony Kay (5-1 3.77 ERA) will head to the hill for the White Sox in this contest. Chicago has won Ray’s previous five starts and he has allowed just six runs (5 ER) across his last 27 plus frames.

Phillies Preview

The Philadelphia Phillies are fresh off a three-game sweep and are nine games out of first place in the NL East Division. On Wednesday, Justin Crawford and Bryce Harper each scored twice during Philadelphia’s 6-4 home victory versus San Diego. SP Zack Wheeler (5-1) struck out eight batters and lasted seven innings to earn the win for the Phillies (33-29), who improved to 17-16 at home.

The Phillies will counter with twenty-eight year old left-hander Jesus Luzardo (4-4 4.30 ERA) on Friday. Last time out, Luzardo (5.1 IP) gave up a pair of runs and fanned six batters during a 4-3 road victory against Los Angeles.

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White Sox vs Phillies Pick

Chicago 1B Munetaka Murakami has landed on the 10-day injured list with a Grade 2 hamstring strain and remains without a timetable to return. Through 62 games, Chicago ranks 5th in OPS and 6th in runs scored. For the season, Philadelphia ranks 28th in OPS and 29th in runs scored. Take the White Sox to pull off the upset on the road. Final Score Prediction, Chicago White Sox win 5-4.

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