Chicago White Sox vs St. Louis Cardinals Picks and Prediction for Sunday, September 13, 2026
The Chicago White Sox visit the St. Louis Cardinals at Busch Stadium on Sunday, with the opening pitch scheduled for 2:15 PM ET on MLB.TV. Chicago is 75-72, first in the AL Central by half a game over Cleveland, but has lost four straight. The White Sox are one game behind the final AL Wild Card position. St. Louis is 73-75, fourth in the NL Central and 19 games behind Milwaukee. The Cardinals are 6.5 games behind the final NL Wild Card spot and opened the series with a 7-3 win Friday. Get ready for Sunday’s matchup with our free MLB picks.
Chicago White Sox Preview
Chicago is batting .235 with a .318 on-base percentage and .405 slugging percentage while scoring 688 runs. The White Sox have hit 192 home runs, giving the lineup a clear source of power. Munetaka Murakami has 31 homers, while Colson Montgomery also has 31 and leads Chicago with 83 RBI. Chase Meidroth provides a different threat, leading the club with a .269 average and 140 hits.
The White Sox pitching staff carries a 4.15 ERA and 1.31 WHIP while holding opponents to a .242 average. Chicago has also posted a .986 fielding percentage with 73 errors. Recent results are the bigger concern, as the White Sox have scored only eight runs during their four-game losing streak. Chicago is 32-41 away from home.
Injuries: SP Drew Thorpe, RP Huascar Brazoban, RP Tyler Davis, LF Tanner Murray and LF Tommy Pham are unavailable.
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St. Louis Cardinals Preview
St. Louis is batting .244 with a .317 OBP and .386 slugging percentage, scoring 675 runs with 156 home runs. Jordan Walker has supplied the most power with 28 homers and 100 RBI while batting .283. Alec Burleson has been the Cardinals’ most productive overall hitter, leading the club with a .284 average, 159 hits and 106 RBI while adding 22 home runs.
The Cardinals enter with a 4.30 ERA and 1.35 WHIP while opponents are batting .255. St. Louis has been stronger defensively, committing 63 errors with a .988 fielding percentage. The Cardinals are 35-38 at Busch Stadium and have dropped three of their last five despite Friday’s victory.
Injuries: RP Peter Strzelecki, 2B JJ Wetherholt, RF Everson Pereira, 3B Blaze Jordan and SP Hunter Dobbins are on the injured list.
Pitching Matchup
Chicago White Sox - Sean Burke
Burke is 8-7 with a 3.58 ERA and 1.20 WHIP across 156 innings. He has allowed 131 hits and 18 home runs while recording 169 strikeouts and 56 walks.
St. Louis Cardinals - Michael McGreevy
McGreevy is 6-9 with a 3.92 ERA and 1.25 WHIP across 154 innings. He has allowed 151 hits and 20 home runs while recording 106 strikeouts and 42 walks.
Chicago White Sox vs St. Louis Cardinals Prediction
Chicago has the stronger starting pitcher, with Burke holding advantages over McGreevy in ERA, WHIP, strikeouts and hits allowed. The White Sox also carry considerably more home-run power, but the current four-game losing streak and 32-41 road record are difficult to overlook. St. Louis has the better defensive numbers and has recently produced more runs. With the Cardinals at home and Chicago’s offense struggling to convert its power into runs, St. Louis has the slight overall advantage in a close series finale. Final Score Prediction: St. Louis Cardinals win, 5-4.
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