Chicago White Sox vs St. Louis Cardinals Picks and Predictions for Saturday, September 12th, 2026
Chicago White Sox vs St. Louis Cardinals Game Information
The Chicago White Sox stay on the road Saturday night with a 7:15 PM matchup inside Busch Stadium in Saint Louis against the Saint Louis Cardinals. Chicago is just above .500 coming into Saturday, fighting for the top spot in the American League Central. The Saint Louis Cardinals are just below .500 this year, currently near the bottom of the National League Central standings. Stay in the news with our MLB Picks.
Chicago White Sox Preview
The Chicago White Sox offense has a .235 batting average this season, scoring 685 runs on 1152 hits. Chicago has a .317 OBP and a .405 team slugging percentage. Chicago pitching has been below average with a 4.13 team ERA this season. Chase Meidroth leads the Chicago offense this season with a .267 batting average. Munetaka Murakami has a .208 batting average and leads the team with 31 home runs. Colson Montgomery has a .209 batting average and leads Chicago with 83 RBIs this season.
St. Louis Cardinals Preview
The Saint Louis offense has a .243 batting average this season after scoring 668 runs on 1208 hits. Saint Louis has a .317 OBP and a .385 team slugging percentage. Saint Louis’s pitching has been its biggest problem, with a 4.31 team ERA. Alec Burleson leads St. Louis this season with a .283 batting average and 104 RBIs. Jordan Walker has a .281 batting average and leads the team with 28 home runs.
Chicago White Sox vs St. Louis Cardinals Pitching Matchup
Luis Castillo will take the mound for Chicago. Castillo is 4-11 with a 5.57 ERA and a 1.46 WHIP across 126 innings. Kyle Leahy will counter for St. Louis. Leahy enters at 10-4 with a 3.41 ERA and a 1.33 WHIP through 132 innings.
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Chicago White Sox vs St. Louis Cardinals Pick
St. Louis has a significant advantage on the mound with Leahy facing a struggling Castillo. The White Sox starter has allowed too much traffic throughout the season and has had trouble keeping the ball in the park. Look for the Cardinals to produce enough offense early and give Leahy a lead, resulting in a home victory Saturday.
- Pick: St. Louis Cardinals -116
- Secondary: Under 8.5
- Lean: Jordan Walker Over 1.5 Bases
Final Score Prediction:
Game Written Before completion of the game on Friday.
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