Chicago White Sox vs Washington Nationals Picks and Prediction for Friday September 26 2025

By: Eddie Kline Published 09/26/2025, 12:55 AM ET

White Sox Preview

In Friday night MLB interleague action, the Chicago White Sox will travel to the nation’s capital to face the Washington Nationals. Be ready for the baseball season with all of our free MLB predictions. The White Sox (58-101) are looking to snap a five-game losing streak and own the worst record in the American League. Last night, Chicago OF Michael Taylor hit a two-run blast during a 5-3 road loss against New York.

Rookie right-hander Yoendrys Gomez (3-3 4.92 ERA) will make his ninth career major league start for the White Sox. Through 56 plus innings, Gomez has retired 53 batters by strikes and owns a 1.39 WHIP.

Nationals Preview

The Washington Nationals have lost 47 of 78 home games and are trapped in the NL East Division basement. On Wednesday, All-Star OF James Wood homered twice as Washington snapped Atlanta’s ten-game winning streak with a 4-3 road victory. 1B Josh Bell added his 21st long ball of the year for the Nationals (65-94).

The Nationals will counter with rookie left-hander Cade Cavalli (3-1 4.23 ERA) on Friday. Washington has won Cavalli’s previous four starts and he has allowed seven runs over his last 20 innings.

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White Sox vs Nationals Pick

Washington SP MacKenzie Gore has been placed on the 15-day injured list with a right ankle impingement. Through 159 games, Chicago ranks 28th in OPS and 28th in runs scored. For the season, Washington ranks 25th in OPS and 20th in runs scored. Take the Nationals to win at home. Final Score Prediction, Washington Nationals win 6-3.

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