Cincinnati Reds vs Chicago Cubs Picks and Prediction for Wednesday May 6 2026
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The Cincinnati Reds and Chicago Cubs continue their National League Central series on Wednesday, May 6, 2026, at Wrigley Field in Chicago, Illinois. First pitch is scheduled for 7:40 PM, and the game will air on MLB.TV. Chicago enters as a -175 favorite on the moneyline, while Cincinnati is listed at +144. The total is set at 8 runs with both the over and under priced at -110. Cincinnati is +1.5 on the run line at -149, while Chicago is -1.5 at +123. Baseball bettors looking for more matchup analysis can also browse the latest free MLB picks for additional betting insight across Wednesday’s schedule.
Starting Pitchers
The pitching matchup features Brady Singer for Cincinnati against Colin Rea for Chicago. Singer enters with a 2-2 record, a 5.57 ERA, and a 1.73 WHIP across 32.1 innings while allowing 47 hits with 20 strikeouts, nine walks, and seven home runs surrendered. Rea comes into the game at 4-1 with a 4.41 ERA and a 1.32 WHIP over 32.2 innings while allowing 34 hits with 30 strikeouts, nine walks, and three home runs allowed. 
Cincinnati Tries to Reverse Recent Struggles
Cincinnati enters this matchup with a 20-15 overall record and a 10-7 record on the road. The Reds recently lost to Chicago 5-4, recently lost to Pittsburgh 1-0, recently lost to Pittsburgh 17-7, recently lost to Pittsburgh 9-1, and recently won over Colorado 6-4. The recent stretch has been difficult for Cincinnati, particularly on the pitching side, with the club allowing significant run totals in several games.
The Reds are batting .220 as a team with 145 runs, 254 hits, 46 home runs, a .306 on-base percentage, and a .385 slugging percentage. Their pitching staff owns a 4.52 ERA with a 1.50 WHIP while allowing opponents to hit .254 against them. Cincinnati pitchers have also issued 166 walks while recording 273 strikeouts. During day games, the Reds are listed at 8-9.
The biggest strength for Cincinnati remains power production. The Reds have hit 46 home runs, matching Chicago in that category, and they are capable of generating quick offense. However, the pitching numbers remain a concern entering this matchup, especially with the higher ERA, WHIP, and walk total compared to the Cubs.
Chicago Continues Excellent Home Form
Chicago enters the game with a 23-12 overall record and a dominant 15-5 mark at home. The Cubs recently won over Cincinnati 5-4, recently won over Arizona 8-4, 2-0, and 6-5, and recently won over San Diego 5-4. Chicago has won five straight games entering Wednesday and continues to play consistently on both sides of the ball.
The Cubs are batting .259 as a team with 190 runs, 310 hits, 46 home runs, a .352 on-base percentage, and a .431 slugging percentage. Their pitching staff carries a 3.89 ERA with a 1.19 WHIP while allowing opponents to hit just .229 against them. Chicago pitchers have also recorded 290 strikeouts while issuing only 104 walks. During day games, the Cubs are listed at 12-8.
Chicago’s biggest advantage is offensive balance combined with overall pitching efficiency. The Cubs lead Cincinnati comfortably in batting average, runs scored, hits, on-base percentage, slugging percentage, ERA, WHIP, and opponent batting average. Their strong home record also adds another edge entering this matchup.
Cincinnati Reds vs Chicago Cubs Picks and Prediction
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Bruce Marshall | +9,181.00 |
| 2 |  Sean Higgs | +4,349.00 |
| 3 |  Bryan Power | +3,755.00 |
| 4 |  Pro Sports Picks | +3,426.00 |
| 5 |  Steve Seagrave | +3,226.00 |
Cincinnati Reds vs Chicago Cubs Pick
- Pick: Chicago Cubs Moneyline
Chicago has been the more complete team entering this matchup and continues to play excellent baseball at home. The Cubs have won five straight games and hold significant statistical advantages offensively and on the mound. The starting pitching matchup also leans toward Chicago, with Colin Rea carrying the lower ERA, lower WHIP, and fewer home runs allowed. Cincinnati’s recent pitching struggles create additional concern against a Cubs offense that has already scored consistently during its winning streak.
Cincinnati Reds vs Chicago Cubs Total Pick
- Pick: Over 8
I am taking the over 8 because Cincinnati’s recent games have regularly produced offense, especially on the opposing side. The Reds have allowed 17, 9, and 5 runs during three of their last four losses, and Brady Singer enters with a 5.57 ERA and seven home runs allowed already this season. Chicago’s offense has also been productive lately, scoring at least five runs in four of its last five games. With both teams capable of hitting for power, this matchup has a strong chance to move beyond the posted total.
Final Score Prediction: Chicago Cubs 6 – Cincinnati Reds 4
This prediction was written before the completion of game play on Tuesday.
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