Cincinnati Reds vs Milwaukee Brewers Picks and Prediction for Saturday, September 12, 2026
The Cincinnati Reds and Milwaukee Brewers meet Saturday at American Family Field, with the opening pitch scheduled for 7:10 PM ET and the game televised on ESPN Unlimited and MLB.TV. Cincinnati is 69-77, fifth in the NL Central and 21.5 games behind Milwaukee, while sitting nine games behind the final NL Wild Card spot. The Reds are 5-5 over their last 10. Milwaukee leads the NL Central at 91-56, 10 games ahead of Chicago, and is 6-4 over its last 10. The Brewers have won three straight, while Cincinnati has lost three in a row. Get ready for Saturday’s matchup with our free MLB picks.
Cincinnati Reds Preview
Cincinnati enters this series with a .230 batting average, .308 on-base percentage and .397 slugging percentage. The Reds have scored 611 runs and hit 196 home runs, giving the lineup plenty of power despite its low overall batting average. Sal Stewart leads Cincinnati with 31 homers and 107 RBI while batting .267. Elly De La Cruz has supplied the best all-around production with a .283 average, .362 OBP, .511 slugging percentage, 26 homers and 25 stolen bases.
The Reds have dropped three straight after being swept by the Dodgers, including a 14-1 loss in their latest game. Cincinnati’s pitching staff has been a major problem, posting a 4.73 ERA and 1.43 WHIP while allowing opponents to bat .252. The Reds have also struggled away from home with a 33-39 road record, adding another concern against the NL Central leaders.
Injuries: 1B Spencer Steer is on the 10-day IL. 1B Michael Toglia, CF Blake Dunn and SP Hunter Greene are on the 60-day IL.
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Milwaukee Brewers Preview
Milwaukee has the stronger offensive numbers, batting .257 with a .339 OBP and .400 slugging percentage while scoring 742 runs. Jackson Chourio leads the Brewers with a .290 average and has 23 home runs, while Jake Bauers has a team-high 24 homers with a .395 OBP. Brice Turang has driven in 86 runs, and William Contreras leads Milwaukee with 141 hits.
The Brewers have won three straight, scoring 16 runs during a sweep of the Cubs. Milwaukee is 50-25 at American Family Field and owns a 3.54 team ERA with a 1.19 WHIP. Opponents are batting only .222 against Brewers pitching. Milwaukee also leads the season series against Cincinnati 7-3 despite dropping the two most recent meetings listed before this series.
Injuries: 1B Jake Bauers is day-to-day. RP Bryse Wilson and RP Grant Anderson are on the 15-day IL. RP Rob Zastryzny and SP Brandon Woodruff are on the 60-day IL.
Pitching Matchup
Cincinnati Reds - Brady Singer
Singer is 6-13 with a 5.03 ERA and 1.47 WHIP across 146.2 innings. The right-hander has allowed 164 hits and 27 home runs while recording 120 strikeouts and 51 walks.
Milwaukee Brewers - Dustin May
May is 6-9 with a 4.69 ERA and 1.32 WHIP across 132.1 innings. The right-hander has allowed 130 hits and 11 home runs while recording 127 strikeouts and 45 walks.
Cincinnati Reds vs Milwaukee Brewers Prediction
Milwaukee has the advantage at home behind the stronger lineup and pitching staff. Singer’s 5.03 ERA, 1.47 WHIP and 27 home runs allowed create a difficult matchup against a Brewers lineup with several productive hitters. May has also been inconsistent, but Milwaukee’s bullpen and overall staff numbers provide a clear edge. Cincinnati has enough power to score, but the Brewers have been much stronger at home and enter on a three-game winning streak. Final Score Prediction: Milwaukee Brewers win, 6-3.
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