Cincinnati Reds vs Minnesota Twins Picks and Predictions for Friday April 17 2026

By: Kim Smith Published 04/17/2026, 12:40 AM ET
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The Cincinnati Reds travel to face the Minnesota Twins at Target Field in Minneapolis, Minnesota on Friday, April 17, 2026, with first pitch scheduled for 8:10 PM and coverage available on MLB.TV. The Twins enter as the home favorite with a moneyline of -175, while the Reds are listed at +144. The total for this matchup is set at 7.5 runs, with the over priced at -115 and the under at -105. On the run line, Minnesota is -1.5 (+123) while Cincinnati sits at +1.5 (-149). This matchup features two teams with identical records but contrasting strengths heading into the game. Be sure to check out the latest free MLB picks for more insight on todayโ€™s games.

Starting Pitchers Breakdown

Cincinnati will send Brandon Williamson to the mound, while Minnesota will counter with Joe Ryan. Williamson enters this matchup with a 1-1 record, a 5.28 ERA, and a 1.37 WHIP across 15.1 innings, allowing 12 hits while striking out 10 and walking 9, along with 3 home runs allowed. Ryan has been more consistent, holding a 2-1 record with a 3.80 ERA and a 0.98 WHIP over 21.1 innings, allowing 15 hits while striking out 22 and issuing 6 walks, along with 1 home run allowed.

Reds Bringing Solid Form on the Road

Cincinnati comes into this matchup with an 11-8 overall record and a strong 5-2 mark on the road. The Reds have gone 3-2 over their last five games, recently winning over San Francisco in back-to-back contests and also picking up a win against Los Angeles, while also recently losing to San Francisco and Los Angeles during that stretch.

Offensively, Cincinnati has struggled to hit for average, posting a .207 team batting average with 64 runs scored and 122 hits, along with 21 home runs. Their on-base percentage sits at .304 with a slugging percentage of .346. On the pitching side, the Reds have recorded a 3.81 ERA and a 1.36 WHIP, while allowing opponents to hit .232. They have issued 81 walks and recorded 140 strikeouts.

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One notable strength for Cincinnati has been their power. Despite a low batting average, they have hit 21 home runs, showing they can generate runs through extra-base hits and long balls.

Twins Looking Strong at Home

Minnesota enters this contest with an 11-8 record and a strong 7-3 mark at home. The Twins have been in good form, going 4-1 over their last five games. They recently won over Boston in two games and also recently picked up wins against Toronto, while only recently losing once to Boston during that stretch.

At the plate, Minnesota is hitting .232 with 103 runs scored and 143 hits, along with 26 home runs. Their on-base percentage is .333 with a slugging percentage of .399. On the pitching side, the Twins have recorded a 4.26 ERA and a 1.41 WHIP, while allowing opponents to hit .259. They have issued 68 walks and recorded 154 strikeouts.

A key strength for Minnesota has been their ability to score runs. With 103 runs and 26 home runs, they have been one of the more productive offenses, particularly at home where they have found consistent success.

Cincinnati Reds vs Minnesota Twins Picks and Prediction

Cincinnati Reds vs Minnesota Twins Pick

Pick: Minnesota Twins Moneyline

Minnesota enters this matchup with a clear edge in offensive production and home performance. While both teams share the same overall record, the Twins have been more effective at scoring runs and have been particularly strong at home. Combined with a more consistent starting pitching performance, Minnesota stands out as the stronger side.

Cincinnati Reds vs Minnesota Twins Total Pick

Pick: Over 7.5

I am leaning toward the over in this matchup because both teams have shown the ability to generate runs, particularly through power. Minnesotaโ€™s high run total and Cincinnatiโ€™s home run production suggest that scoring opportunities should be present. With a relatively low total set at 7.5, this game has a strong chance to go over.

Final Score Prediction: Minnesota Twins 5 โ€“ Cincinnati Reds 4

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