Cincinnati Reds vs St. Louis Cardinals Picks and Predictions for Monday, September 15, 2025
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The Cincinnati Reds and St Louis Cardinals open their series Monday night at Busch Stadium in St. Louis, with the first pitch at 7:45 PM ET on MLB.TV. Cincinnati comes in at 74–74 overall and 34–40 on the road, while St. Louis sits at 72–77 with a solid 41–34 home record. Win big with our free MLB Pick.
Cincinnati Reds Preview
Cincinnati has dropped two straight in Oakland, giving up 14 runs in the process. Zack Littell gets the start with a 9–8 record and 3.78 ERA across 171.1 innings. He has kept his walks down (29) but has been vulnerable to the long ball (34 homers allowed). The Reds’ pitching staff has been reliable overall with a 3.96 ERA and 1.24 WHIP. Cincinnati trails first place in the National League Central by 16.5 games, but is just 1.5 games behind the third and final NL wild card spot.
Offensively, the Reds have the talented Elly De La Cruz, who is batting .265 with 19 home runs, 82 RBI, and 35 stolen bases. TJ Friedl leads with a .366 on-base percentage, while Spencer Steer and Noelvi Marte provide additional power. As a team, Cincinnati sits at .246/.316/.390 with 148 home runs, but has been inconsistent on the road.
St. Louis Cardinals Preview
St. Louis has lost five straight, including back-to-back extra-inning defeats in Milwaukee. Matthew Liberatore takes the ball with a 7–12 record and 4.35 ERA in 140.2 innings. He has allowed 38 walks and 18 home runs, so control will be key. The Cardinals’ staff carries a 4.30 ERA and 1.32 WHIP, a step below Cincinnati. St Louis is 19 games behind first place in the National League Central, but just four games behind the 3rd and final NL wild card spot
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The offense has been carried by Willson Contreras (20 home runs, 79 RBI) and Alec Burleson (.283/.333/.453). Brendan Donovan leads with a .348 on-base percentage. The lineup is missing Nolan Arenado, who is on the 10-day injured list, leaving the Cards thin on right-handed power. As a team, St. Louis is batting .245/.314/.380 with 140 home runs.
Cincinnati Reds vs St. Louis Cardinals Prediction
With both teams struggling, home-field advantage and a slightly deeper lineup give St. Louis the advantage. However, Cincinnati has a solid lineup led by Elly De La Cruz and cannot be overlooked. However, in the end, the Cardinals will pull out a win in the late innings. Final Score Prediction: St. Louis Cardinals win 4-2.
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