Cleveland Guardians vs Boston Red Sox Picks and Predictions for Wednesday, September 3, 2025

By: David Anicetti Published 09/03/2025, 12:05 AM ET

Guardians Preview

The Cleveland Guardians complete a three-game series on the road Wednesday versus the Boston Red Sox. Cleveland is 68-68 following Monday’s 6-4 loss to Boston in the opening game of the series. Cleveland has lost two straight and eight of the last 12. The Guardians are 10.5 games behind first place in the American League Central and trail the third and final AL wild card spot by four games. Keep up to date with all the MLB action with our MLB predictions.

Jose Ramirez is batting .280 with 26 home runs, 68 RBI, and an on-base percentage of .355 to lead Cleveland in each of the four categories. Steven Kwan is the leader in hits with 142. Cleveland is batting .223 with a .366 slugging percentage. On Wednesday, the Cleveland Guardians will send Logan Allen to the mound. The left-hander is 7-10 with a 4.42 ERA, 105 Ks, and 57 BBs.

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Red Sox Preview

The Boston Red Sox improved to 77-62 following Monday’s two-run victory over Cleveland. Carlos Narvaez hit a fifth-inning tie-breaking single for his first career pinch hit, to help lead Boston to the victory. The Red Sox have six of the last eight. Boston trails first place in the American League East by 2.5 games and currently holds the first of three AL wild card spots.

Jarren Duran is batting .260 with 138 hits and an on-base percentage of .337 to lead Boston in each of the three categories. Trevor Story leads in home runs with 23 and RBI with 86. Boston is batting .253 with a .425 slugging percentage. Boston has not announced its starting pitcher for the final game of a three-game series on Wednesday at home versus the Cleveland Guardians.

Red Sox vs Guardians Trends

Cleveland is 5-11 in its last 16
The UNDER has cashed in 5 of the Guardians’ last 6 in September
Boston is 9-3 in its last 12
The UNDER has cashed in 6 of the Red Sox’s last 8

Red Sox vs Guardians Prediction

Boston has won nine of its last 12 overall and each of its last five versus an opponent from the American League. Cleveland has lost four of the last six versus Boston, each of the last six played on the road, and 11 of the last 16 overall. Cleveland starter Logan Allen has been roughed up in each of the last two outings, allowing 13 runs on 12 hits across 11.0 innings. Final Score Prediction: Boston Red Sox win 7-3.

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