Cleveland Guardians vs Detroit Tigers Picks and Predictions for Wednesday, September 17, 2025
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The Cleveland Guardians visit the Detroit Tigers on Wednesday afternoon at Comerica Park. The first pitch is at 6:40 PM ET with television coverage on FS1. Cleveland enters at 78–71 overall and 37–37 away from home, while Detroit sits at 85–65 and holds a strong 46–29 record at Comerica. The game features Cleveland left-hander Logan Allen against Detroit right-hander Jack Flaherty. Cleveland is battling for one of three American League wild card spots, but trails the final spot by three games, while Detroit is on the verge of clinching the AL Central crown. Run the bases and win with our expert MLB Picks.
Cleveland Guardians Preview
Logan Allen has had an up-and-down season with a 7–11 record, 4.43 ERA, and 1.44 WHIP across 144.1 innings. He’s given up 18 home runs and 59 walks, which has hurt his effectiveness, but his strikeout total of 111 shows he can still get swings and misses. Cleveland leans heavily on its staff as a whole, carrying a team ERA of 3.80, WHIP of 1.29, and opponents hitting just .242, all numbers that have kept them in playoff contention.
At the plate, the Guardians remain a light-hitting lineup. As a team, they’re batting just .225 with 154 homers and 580 runs. José Ramírez continues to be the spark, hitting .281 with 28 home runs, 77 RBI, and a .499 slugging percentage. Steven Kwan leads in hits with 156 and has 19 stolen bases. Cleveland has won four of its last five, with three straight against the White Sox, followed by a sweep of Kansas City, showing that they can pull out close, low-scoring wins even with limited power.
Detroit Tigers Preview
Jack Flaherty has an 8–13 record with a 4.69 ERA and 1.28 WHIP over 151.2 innings. While his ERA is higher than expected, his strikeout count is exceptional - 178 Ks against just 55 walks. Detroit’s overall pitching has been steady with a 3.91 ERA, 1.24 WHIP, and opponents hitting .240. At home, run prevention has been more consistent, making them tough to beat in low-scoring games.
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The Tigers’ offense gives them an even bigger edge. Detroit ranks ahead of Cleveland in most categories, batting .249 with 187 home runs and 729 runs scored. Riley Greene leads the way with 34 homers, 108 RBI, and an .825 OPS. Spencer Torkelson and Kerry Carpenter add more punch in the middle of the order, while Gleyber Torres provides on-base skills with a .362 on-base percentage. Detroit has split results recently, but did complete its series in Miami with a shutout win.
Cleveland Guardians vs Detroit Tigers Prediction
Detroit has the better offense and a deeper roster. Greene, Torkelson, and Carpenter make it harder for opposing pitchers to shut down the lineup, while Flaherty’s strikeouts give him a chance to keep Cleveland’s light-hitting lineup quiet. The Guardians have relied on pitching all year, but the Tigers’ power and home record make them the option in this matchup. Final Score Prediction: Detroit Tigers win 6-3.
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