Cleveland Guardians vs Houston Astros Picks and Predictions for Sunday, June 21, 2026

By: Cameron Ross Published 06/21/2026, 01:30 AM ET
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Guardians vs Astros Game Information

The Cleveland Guardians stay on the road Sunday with a 2:10 PM matchup against the Houston Astros in Houston, TX. Cleveland has 41 wins and 36 losses this season and, after Saturday's victory, has won 2 of the last 3. The Houston Astros stay home Sunday, 6 games below .500 after Saturday's loss, ending a 3-game winning streak. Stay up to date with our MLB Picks.

Guardians Preview

The Cleveland offense has compiled a .229 batting average this year, scoring 301 runs on 569 hits. Cleveland has a .314 OBP and a .370 team slugging percentage. Cleveland's pitching has been the team's biggest strength this year, with a 3.85 team ERA, and they've allowed just 3 runs over their last 2 wins. Brayan Rocchio leads the Cleveland offense this season with a .273 batting average. Angel Martinez has a .239 batting average and leads the team with 11 home runs. Chase DeLauter has a .263 batting average and leads the way with 34 RBI's.

Astros Preview

The Houston Astros offense has a .244 batting average this season, scoring 353 runs on 633 hits. Houston has a .319 OBP and a .416 team slugging percentage. The Houston pitching staff has struggled this season, posting a 4.85 team ERA, and they've allowed 17 runs in their last 2 losses. Yordan Alvarez is carrying the Houston offense this season, leading the team with a .320 batting average, 24 home runs, and 55 RBI's.

Guardians vs Astros Pitching Matchup

Slade Cecconi will take the mound for Cleveland on Sunday. This year, Cecconi has struggled, posting 3 wins, 5 losses, and a 4.60 ERA over 78.1 innings. Kai-Wei Teng will counter for Houston. Teng is 3-6 this season with a 4.31 ERA over 54.1 innings.

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Guardians vs Astros Pick

Cleveland is the better team in this matchup, but Houston has been playing better baseball of late. Look for Houston to ride their hot streak and better offense on Sunday. Houston must begin to make their push if they are going to be a playoff team in October. Take the Astros to continue their winning ways as they close this series with another victory Sunday afternoon at home against the Guardians.

  • Pick: Houston Astros
  • Secondary: Β Over
  • Lean: Yordan Alvarez Over .5 RBIs

Final Score Prediction:Β  Houston Astros win 8-4.

Game Written Prior to completion of game on Saturday.

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