Cleveland Guardians vs Minnesota Twins Picks and Predictions for Saturday, September 12th, 2026

By: Cameron Ross Published 09/12/2026, 12:50 AM ET

Cleveland Guardians vs Minnesota Twins Game Information

The Cleveland Guardians continue their road series Saturday with a 4:10 PM matchup at Target Field in Minneapolis, MN, against the Minnesota Twins. Cleveland enters the game above .500 at 75-73, just 1 game behind first place in the American League Central. Minnesota remains at home Saturday, below .500 and 6.5 games back in the division after Friday's loss in game 1 of this set. For more MLB news, see our MLB Picks.

Cleveland Guardians Preview

The Cleveland offense has a .237 batting average this season and has scored 598 runs on 1160 hits. Cleveland has a .314 OBP and a .372 team slugging percentage. Cleveland's pitching has been the team’s biggest strength, with a 3.80 team ERA, and they've allowed 9 runs across their last 3 wins. Chase DeLauter leads Cleveland this season with a .293 batting average. Angel Martinez has a .248 batting average and leads the team with 15 home runs. Brayan Rocchio has a .247 batting average and leads the team with 64 RBI's.

Minnesota Twins Preview

The Minnesota Twins have a .245 batting average this season, having scored 675 runs on 1204 hits. Minnesota has a .319 OBP and a .407 slugging percentage. The Minnesota pitching has been bad, with a 4.67 team ERA this year. Luke Keaschall leads Minnesota with a .272 batting average. Kody Clemens has a .243 batting average and leads the team with 26 home runs. Josh Bell has a .255 batting average and leads Minnesota with 86 RBI this year.

Cleveland Guardians vs Minnesota Twins Pitching Matchup

Gavin Williams will take the mound Saturday for Cleveland. Williams is 13-7 this season with a 3.78 ERA, 1.09 WHIP, and 228 strikeouts across 169 innings. Connor Prielipp will get the start for Minnesota. Prielipp is 4-7 with a 5.25 ERA and a 1.36 WHIP through 108 innings.

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Cleveland Guardians vs Minnesota Twins Pick

Cleveland has the more dependable starter and enters this matchup with much more at stake in the division race. Williams has consistently pitched well this year, while Prielipp has struggled to keep opposing lineups off the scoreboard. Take Cleveland to win its second consecutive game in Minnesota.

  • Pick: Cleveland Guardians -1.5
  • Secondary: Over
  • Lean: Chase DeLauter Over 1.5 bases

Final Score Prediction: Cleveland Guardians win 6-3.

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