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Cleveland Guardians vs Tampa Bay Rays Picks and Prediction for Thursday September 4 2025

By: Eddie Kline Published 09/04/2025, 12:20 AM ET

Guardians Analysis

In Thursday afternoon MLB action, the Cleveland Guardians will travel to Steinbrenner Field to take on the Tampa Bay Rays. Be ready for the baseball season with all of our MLB predictions. The Guardians (69-69) are two games below .500 on the road and are 3.5 games back in the race for the final AL Wild Card spot. Last night, leadoff hitter Steven Kwan collected three hits and scored twice to spark Cleveland to an 8-1 road triumph against Boston.

Twenty-six year old righty Gavin Williams (9-5 3.26 ERA) will take the mound for the Guardians in this matchup. In his last start, Williams (7 IP) allowed one run and struck out eight batters during a 4-3 home victory versus Seattle.

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Rays Analysis

The Tampa Bay Rays are riding a six-game winning streak and trail Seattle by 2.5 games for the final AL Wild Card spot. On Wednesday, DH Yandy Diaz collected five of Tampa Bay’s 18 hits during a 9-4 home victory versus Seattle. Emerging star Junior Caminero went 2-for-5 with two runs scored and a pair of RBIs for the Rays (70-69), who improved to 37-33 at home.

Tampa Bay manager Kevin Cash will turn to right-hander Ryan Pepiot (10-10 3.70 ERA) on Thursday. Through 158 innings of work, Pepiot has fanned 155 batters and owns a solid 1.15 WHIP.

Rays vs Guardians Pick & Prediction

Cleveland OF Lane Thomas (foot) is on a rehab assignment with Double-A Akron and should return to the lineup this weekend. Through 138 games, Cleveland ranks 29th in OPS and 27th in runs scored. For the season, Tampa Bay ranks 14th in OPS and 13th in runs scored. Take the over. Final Score Prediction, Tampa Bay Rays win 6-4.

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