Cleveland Guardians vs Tampa Bay Rays Picks and Predictions for Friday, September 5, 2025
Guardians vs Rays Game Information
The Cleveland Guardians play the second game of a four-game series on the road Friday versus the Tampa Bay Rays. The first pitch is scheduled for 7:35 p.m. and will be televised on BSFL. Stay on pace with all of baseball’s latest action using our MLB picks.
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Guardians Preview
Cleveland is 69-69 and defeated the Boston Red Sox 8-1 on Wednesday, avoiding a three-game sweep after losing the first two games of the series to Boston. Cleveland has won just one of its last four games. The Guardians trail first-place in the American League Central by 10.5 games and are three games behind the third and final AL wildcard spot with 24 games remaining.
Jose Ramirez leads Cleveland in several hitting categories, including home runs with 26, RBI with 70, on-base percentage with .353, and batting average at .278. Kyle Manzardo is second in home runs with 24 and second in RBI with 61. Cleveland has struggled at the plate this season, ranking 29th, which is next to last, in slugging percentage (.369) and last in batting average (.224).
Rays Preview
Tampa Bay is 70-69 after defeating the Seattle Mariners 9-4 on Wednesday to complete a three-game sweep of that series. The Rays have won six straight but are 10.5 games behind first place in the American League East. Tampa trails the third and final wild card spot in the AL by 2.5 games with 23 games remaining on its schedule.
Junior Caminero has 40 home runs and 102 RBI to lead Tampa Bay in both categories. Brandon Lowe is second in home runs with 28, and Yandy Diaz is second in RBI with 76. Tampa Bay is 7th in batting average (.253) and 14th (.404) in slugging percentage. On the mound, Tampa Bay has the third-best WHIP (1.21) and 12th-best ERA (3.89).
Guardians vs Rays Pitching Matchup
Gavin Williams will start on the mound for Cleveland on Friday. The right-hander is 9-5 with a 3.24 ERA, 143 strikeouts, and 1.29 WHIP. Williams has had three consecutive solid appearances, giving up four runs across 15.2 innings, with Cleveland winning two of the three. Ian Seymour starts on the mound for Tampa Bay on Friday. The left-hander is 3-0 with a 2.97 ERA, 1.02 WHIP, and 42 strikeouts. In his only two starts of the season, which were his most recent two outings, Seymour has allowed only one run in 10 innings.
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vincilleti | +2,913.00 |
| 2 |  Ross Benjamin | +1,550.00 |
| 3 |  Dan Kaiser | +1,258.00 |
| 4 |  Chip Chirimbes | +1,071.00 |
| 5 |  Ben Burns | +712.00 |
Rays vs Guardians Odds
Cleveland is +105 and Tampa Bay is -115. The over/under total is 8.5
Rays vs Guardians Pick & Prediction
Tampa Bay is a solid choice as the Rays have won six straight leading up to this series. Tampa Bay will have Ian Seymour on the mound. The left-hander has made 14 appearances this season with only two starts. The two starts were his most recent appearances, and the southpaw gave up only five hits and one run over 10 innings with Tampa Bay winning both. The under is another solid play as the total has finished under in 9 of the last 11 games between the two American League rivals.
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