Colorado Rockies vs. San Francisco Giants Picks and Predictions for Friday September 26, 2025

By: Dylan Hellebrand Published 09/26/2025, 12:40 AM ET
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On Friday, the Colorado Rockies (43-114) face off against the San Francisco Giants (77-81) at Oracle Park in San Francisco, California. The game will be aired on Rockies.TV and NBC Sports Bay Area. Keep up to date with all the MLB action, with our MLB picks.

Game Information For Rockies vs Giants 

  • September 26, 2025, 10:15pm EST
  • Oracle Park, Rockies
  • TV/NBC Sports Bay Area
  • 72° sunny at start time

San Francisco Form & Recent Results

San Francisco enters this matchup struggling, having lost their last two games and dropping four out of their previous five leading up to the series finale with St. Louis. In Tuesday’s 9-8 defeat against the Cardinals, Heliot Ramos had a standout performance for the Giants, notching two hits in five at-bats, including a home run, while scoring twice and driving in a run. This season, Willy Adames has been the Giants’ primary power threat at the plate, leading the team with 28 home runs, while Matt Chapman ranks second in that category with 21 homers so far. Adames has also established himself as the team’s top run producer, tallying 84 RBIs to pace San Francisco. Jung Hoo Lee boasts the highest batting average among Giants regulars, hitting .261 on the year. Pitching has been a concern in recent games, as the Giants have given up an average of 5.8 runs per contest over their last five games, a trend that has contributed to their declining postseason hopes. Overall, San Francisco is averaging 4.3 runs scored per game this season.

Colorado Form & Recent Results

Colorado heads into this matchup carrying a one-game losing streak, having dropped three out of their last five games heading into the final two games of their series against the Seattle Mariners. Most recently, the Rockies suffered a narrow 4-3 defeat to Seattle on Tuesday. In that matchup, Ezequiel Tovar provided a bright spot for the team by going 1-for-3 at the plate and driving in two of Colorado’s three runs. Offensively this season, Hunter Goodman has been the team’s top power threat, leading the Rockies with 30 home runs so far. Mickey Moniak has served as a solid complement in the lineup, contributing 24 homers, making him the club’s second-leading home run hitter. Goodman has also stood out as the Rockies’ RBI leader with 88 runs batted in, and he currently boasts a team-high .279 batting average. Defensively, the Rockies’ pitching staff has struggled, allowing an average of 4.6 runs per game over their last five. As the season nears its conclusion, Colorado will be looking to finish on a positive note and mitigate what has been a difficult season to say the least. Overall, the Rockies’ offense has underperformed, averaging just 3.7 runs per game throughout the year.

Starting Pitchers

  • Colorado’s German Marquez in last 7 days: 0-1, 2.57 ERA, 5 K
  • San Francisco’s Kai-Weng Tei in last 7 days: 0-0, 6.00 ERA, 6 K

Giants vs Rockies Picks and Prediction

Colorado is wrapping up what’s been, without question, their toughest season yet, desperately searching for a positive finish as they travel to San Francisco. Meanwhile, the San Francisco Giants are almost mathematically eliminated from playoff contention, but they’ll aim to capitalize on Colorado’s misfortunes and give their home fans something to cheer about at Oracle Park. On the mound, the Rockies will send out German Marquez, who has struggled significantly this year, posting a disappointing 3-15 win-loss record along with a high 6.49 ERA. The Giants will counter with Kai-Wei Teng, who hasn’t fared much better, going 2-4 with a 6.37 ERA. Final Score Prediction, San Francisco Giants win 4-2.

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