Game One Cleveland Guardians vs Minnesota Twins Picks and Prediction for Saturday September 20 2025
Guardians Preview
In the first game of a Saturday doubleheader, the Cleveland Guardians will battle the Minnesota Twins from Target Field. Be ready for the baseball season with all of our MLB predictions. The Guardians (82-71) have reeled off eight straight victories and trail Boston by one game for the final AL Wild Card spot. Last night, C Bo Naylor went 2-for-4 with four RBIs to lead Cleveland to a 6-2 road victory against Minnesota.
Twenty-seven year old righty Logan Allen (7-11 4.36 ERA) will take the mound for the Guardians in this matchup. The Guardians have dropped four of Allen’s previous five starts and he has surrendered 22 runs across his last 25 plus frames.
Twins Preview
The Minnesota Twins pressed the reset button at the trade deadline and have been eliminated from postseason contention. During Friday’s home loss, Minnesota batters were limited to six hits and retired by strikes and alarming 16 times. 3B Royce Lewis went 2-for-4 with an RBI for the Twins (66-87), who fell to 37-41 at home.
Minnesota manager Rocco Baldelli will turn to talented right-hander Joe Ryan (13-8 3.35 ERA) in the opening game. Last time out, Ryan gave up two runs and lasted just four innings during a 5-2 home loss versus Arizona.
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Guardians vs Twins Pick
Cleveland OF Lane Thomas (foot) will be forced to see a specialist and his status to return is unclear. Through 153 games, Cleveland ranks 29th in OPS and 27th in runs scored. For the season, Minnesota ranks 16th in OPS and 18th in runs scored. Take the Twins to win at home. Final Score Prediction, Minnesota Twins win 5-3.
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