Houston Astros vs Athletics Picks and Prediction for Tuesday September 23 2025

By: Thomas Pemberton Published 09/23/2025, 12:35 AM ET
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The Houston Astros head to Sacramento on Tuesday to take on the Athletics in a three game series. Houston is a small road favorite and the total is set at 10 runs. The Astros seek payback after losing to the Athletics 7-1 in their last meeting back in late July. Be sure to check out our expert's MLB Free Picks. 

Houston Astros Preview

The Houston Astros are 2nd in the AL West with a 84-72 record. Houston is 5-5 over their last ten games and they carry a winning 38-37 road record. The Astros enter Sacramento riding a three game losing streak. Houston ranks 8th in the MLB averaging 8.5 hits per game.Jose Altuve leads Houston on the season with 26 home runs. Cristian Javier will make his 8th start on the mound for the Houston Astros. Javier is 2-3 on the season with 32.1 innings pitched. Javier has 30 strikeouts and carries a 4.45 ERA. Javier has pitched 6 innings in two straight starts. The Houston Astros carry a 3.87 team ERA.

Athletics Preview

The Athletics are 4th in the AL West with a 73-83. The Athletics have won seven of their last ten games but have lost two straight games. The Athletics carry a 33-42 home field record. The Athletics are averaging 8.7 hits per game which is 5th best in the MLB. Brent Rooker leads the A's with 162 hits on the season. Jeffrey Springs will make the start on the hill for the Athletics. Springs is 10-11 on the season with 166 innings pitched. Springs has 135 strikeouts, 52 walks, and carries a 4.18 ERA. Springs pitched 4 innings in his last outing allowing 5 hits and 1 run. The A's carry a 4.72 team ERA.

Astros vs Athletics Free Picks & Prediction

Both the Astros and Athletics enter this series riding losing streaks. Houston has been outscored 17-7 over their last three games. While the Athletics have been outscored 13-0 over their last two games. Houston is the better team and show the best value.

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  • Final Score Prediction: Houston Astros win 6-1.

Astros vs Athletics Best Pick:

  • Houston Astros -101
  • UNDER 10

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