Houston Astros vs Athletics Picks and Predictions for Saturday, September 26th, 2026

By: Cameron Ross Published 09/26/2026, 03:30 AM ET

Houston Astros vs. Athletics Game Information

They Astros will be on the road Saturday night with a 9:40 PM matchup in Sacramento against the Athletics. Houston is hovering around .500 in contention for the American League West title. The Athletics are 1 of the worst teams in baseball, coming into Saturday nearly 30 games below .500 this season. Stay in the news with our MLB Picks.

Houston Astros Preview

Peter Lambert got the start for Houston in their last outing, giving up 4 runs on 6 hits over 2.2 innings. After that, the Houston bullpen was much better, giving up only 1 run on 5 hits over the final 6.1 innings. Lucas Spence erupted last time out for Houston, leading the team with 3 hits and driving in 5 runs. Isaac Paredes and Christian Walker chipped in, driving in 1 run each.

Athletics Preview

Mason Barnett got the start for the Athletics last time out, giving up 4 runs on 4 hits over 6 innings. The rest of the Athletics bullpen struggled as well, giving up three more runs on six hits over the final three innings. Jeff McNeil led the Athletics offense in their last outing with 2 hits and 3 runs driven in. Zach Gelof chipped in as well with 2 hits to drive in 2 more runs.

Houston Astros vs Athletics Pitching Matchup

The Houston Astros have yet to announce a pitcher for this matchup and could rely heavily on their bullpen in Game 2 of this set. The Athletics have set Jack Perkins to start Saturday. This season, Perkins is 3-12 overall with a 5.90 ERA across 116 innings.

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Houston Astros vs Athletics Pick

Houston gets the preliminary edge based on its stronger overall record and the importance of every game during the final weekend. The Athletics have enough offensive talent to make this competitive, particularly at home, but Houston has the more accomplished roster. The absence of confirmed starters makes this a weaker selection right now. If a pick is required before the pitching matchup is announced, the Astros are the narrow choice, with the expectation that this matchup should be reevaluated once both starters are known.

  • Pick: Houston Astros
  • Secondary: Pending Starters
  • Lean: Houston Astros Team Total Over

Final Score Prediction: Houston Astros win 5-4

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