Houston Astros vs Atlanta Braves Picks and Predictions for Friday, September 12, 2025

By: David Anicetti Published 09/12/2025, 12:15 AM ET
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Astros vs Braves Game Information

The Houston Astros open a three-game series on the road Friday versus the Atlanta Braves at Truist Park with the first pitch at 7:15 PM ET. Houston is 79-67 (36-35 away) and Atlanta is 65-81 (35-37 home). The Astros carry a 3.83 team ERA and 1.22 WHIP, while the Braves sit at 4.44 and 1.31. Houston is still undecided on its starting pitchers, while Atlanta will send right-hander Hurston Waldrep, who’s been excellent at 4-0 with a 1.33 ERA, 1.06 WHIP, 38 strikeouts, and just two home runs allowed in 40.2 innings. Be ready for all that the baseball season has left by checking out our free MLB Picks.

Houston Astros Preview

Houston has a strong pitching staff and enough at the plate to create problems for opponents. The Astros' slash line is .253/.318/.401 with 162 home runs, led by José Altuve’s 24 home runs and team-high 143 hits. Jeremy Peña has been steady at .299/.358/.464, while Yainer Díaz (19 HR) and Christian Walker (76 RBI) add power. Yordan Álvarez’s .289/.381/.456 line in limited action is hard to overlook

Houston has not announced its starting pitcher but the staff has held opponents to a .231 batting average, and the bullpen has performed well of late as the Astros attempt to hold off the Seattle Mariners at the top of the American League West, but currently leading by just one game.

Atlanta Braves Preview

Atlanta needs starter Waldrep to keep the game close and hand it off to the bullpen with a lead. Atlanta has dropped four of five, including two losses to the Cubs, so limiting free walks is critical. Waldrep has performed well, but 16 walks in 40.2 innings means he needs to show better control against the middle of the Astros’ lineup.

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The Braves own a .242/.317/.391 team line with 162 homers. Matt Olson leads the team in hits (151), home runs (23), RBI (81), and on-base percentage (.368). Ozzie Albies has 16 homers, and Marcell Ozuna has 20, giving the Braves plenty of power.

Houston Astros vs Atlanta Braves Prediction

Houston’s superior pitching stats and a more reliable top half of the batting order give the Astros a much better chance of coming out on top. If Houston’s hitters are patient and make Waldrep find the plate, the Astros will get enough hitting opportunities to score enough on the road to win. Final Score Prediction: Houston Astros win 5-4.

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