Houston Astros vs Baltimore Orioles Picks and Predictions for Tuesday April 28 2026

By: Jeremy O'Quinn Published 04/28/2026, 01:40 AM ET
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Houston Astros Preview

The Houston Astros will travel to Camden Yards on Tuesday, where they’ll open a series against the Baltimore Orioles. Get the rest of our free MLB picks here! Houston enters this matchup struggling at 11-18 on the season, while Baltimore has been one of the stronger teams in the American League, sitting above .500 and continuing to play well at home. Despite some offensive production, Houston has been inconsistent overall, averaging roughly 8.3 hits and around 4.2 runs per game. However, Houston’s injury depleted pitching staff has struggled badly, posting one of the worst team ERAs in the MLB. Due to those injuries, Houston is expected to send Kai-Wei Teng to the mound on Tuesday. Teng has been used primarily out of the bullpen this season but has been effective, posting a 2.16 ERA with 16 strikeouts over 16.2 innings.

Baltimore Orioles Preview

The Orioles come into this matchup as the more balanced team, combining strong offense with more reliable pitching. Baltimore is averaging 8.7 hits and 4.8 runs per game, ranking among the better offensive teams in the American League. Their lineup continues to produce consistently, with contributions across the board, including power from the middle of the order and strong situational hitting. Baltimore is projected to counter with Shane Baz on the mound, who’s posted a 5.08 ERA through 28 innings of play this season. In the 2025 season, Baz posted a 4.87 ERA with the Tampa Bay Rays.

Astros vs Orioles Pick

Baltimore is at home where they hope to bounce back after dropping consecutive games, while the Astros look to build off a big over the Yankees on Sunday. Expect Teng to be strong on the mound, leading Houston to the upset victory. Final score prediction, Astros win 4-3. The play here is Houston +115.

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