Houston Astros vs Cincinnati Reds Picks and Prediction for Sunday, May 10, 2026

By: Jake Allman Published 05/10/2026, 01:25 AM ET

The Houston Astros and Cincinnati Reds continue this interleague series Sunday at Great American Ball Park. Houston comes into the matchup at 16-23 overall after a dominant 10-0 win on Friday, while Cincinnati sits at 20-19 and has now dropped five straight games. Bettors searching for free MLB picks should pay attention to Houston’s offensive advantage entering this afternoon matchup. Elevate your MLB game with our top-notch MLB picks.

First pitch is scheduled for 1:40 p.m. ET with coverage on MLB.TV. Cincinnati is listed as a slight favorite at home according to ESPN’s matchup predictor, but recent form tells a different story. Great American Ball Park remains one of the more hitter-friendly parks in baseball, which always keeps totals in play.

Astros Preview

Houston continues to rely heavily on the middle of the lineup, especially Yordan Alvarez. The Astros slugger enters Sunday with 13 home runs, 29 RBI, and a .324 batting average while helping Houston produce a .264 team average and .439 slugging percentage. Houston has also scored 195 runs this season compared to only 156 for Cincinnati, which is a major difference between these teams right now.

The Astros still have pitching concerns with no confirmed starter announced, but the lineup has carried the team recently. Houston has won three of the last five games and already handled Cincinnati comfortably in this series. The Astros are also 8-8 during day games this season, giving bettors another solid angle for an early start.

Subscribe Now

I authorize Picks And Parlays to send me promotional emails

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Terms & Conditions

Reds Preview

Cincinnati turns to left-hander Andrew Abbott, who enters with a 1-2 record, 5.13 ERA, and 1.64 WHIP through 40.1 innings. Abbott has already allowed 47 hits and 19 walks this season, which could become a problem against a patient Houston lineup. Cincinnati’s offense has struggled badly during this losing streak after scoring three runs or fewer in four straight games before Friday’s shutout loss.

Elly De La Cruz remains the top power threat for the Reds with 10 home runs and 28 RBI, but Cincinnati is batting only .218 as a team. The Reds also own a 4.73 ERA and have not received consistent pitching over the last two weeks. Houston clearly enters this matchup with more momentum and better offensive production.

Best Picks

Astros Moneyline
Over 9 Runs

Prediction: Astros 6, Reds 4

Never Tried Picks and Parlays? Now Is Your Chance

Get your first daily picks package for ONLY $1 using coupon code BUCK
If the pick loses, we credit your account with 3 Flex Picks
If the pick wins, we still give you 1 Flex Pick on the house
Win or lose, you walk away ahead. One dollar. No catch.

Min. Deposit $5

Cashable No

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.

Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)

Cashable No

Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelplineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-HOPENY or text HOPENY (467369) (NY). 21+ (18+ DC, IA, KY, WV) only. New users only or text HOPENY (467369) (NY). Casino, First online real money wager only. $5 first deposit required. Min $5 wager required for 5 consecutive days. Bonus issued as non-withdrawable Bet Reset tokens. Refund from token issued as nonwithdrawable bonus bet that expire 7 days after receipt. Max refund $200 per day. Restrictions apply, including token expiration. See full terms at fanduel.com/sportsbook. Call 1-877-770-7867 (LA).

Min. Deposit $5

Cashable No

GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $150 issued as non-withdrawable Bonus Bets that expire in 7 days after issuance. Stake removed from payout. Reward issued as $50 in Bonus Bets every 7 days via click-to-claim for 14 days. 7 days = 168hrs. Terms: sportsbook.draftkings.com/promos. Ends 8/23/26 at 11:59 PM ET. Sponsored by DK.