Houston Astros vs Cincinnati Reds Picks and Prediction for Sunday, May 10, 2026

By: Jake Allman Published 05/10/2026, 01:25 AM ET

The Houston Astros and Cincinnati Reds continue this interleague series Sunday at Great American Ball Park. Houston comes into the matchup at 16-23 overall after a dominant 10-0 win on Friday, while Cincinnati sits at 20-19 and has now dropped five straight games. Bettors searching for free MLB picks should pay attention to Houston’s offensive advantage entering this afternoon matchup. Elevate your MLB game with our top-notch MLB picks.

First pitch is scheduled for 1:40 p.m. ET with coverage on MLB.TV. Cincinnati is listed as a slight favorite at home according to ESPN’s matchup predictor, but recent form tells a different story. Great American Ball Park remains one of the more hitter-friendly parks in baseball, which always keeps totals in play.

Astros Preview

Houston continues to rely heavily on the middle of the lineup, especially Yordan Alvarez. The Astros slugger enters Sunday with 13 home runs, 29 RBI, and a .324 batting average while helping Houston produce a .264 team average and .439 slugging percentage. Houston has also scored 195 runs this season compared to only 156 for Cincinnati, which is a major difference between these teams right now.

The Astros still have pitching concerns with no confirmed starter announced, but the lineup has carried the team recently. Houston has won three of the last five games and already handled Cincinnati comfortably in this series. The Astros are also 8-8 during day games this season, giving bettors another solid angle for an early start.

Reds Preview

Cincinnati turns to left-hander Andrew Abbott, who enters with a 1-2 record, 5.13 ERA, and 1.64 WHIP through 40.1 innings. Abbott has already allowed 47 hits and 19 walks this season, which could become a problem against a patient Houston lineup. Cincinnati’s offense has struggled badly during this losing streak after scoring three runs or fewer in four straight games before Friday’s shutout loss.

Elly De La Cruz remains the top power threat for the Reds with 10 home runs and 28 RBI, but Cincinnati is batting only .218 as a team. The Reds also own a 4.73 ERA and have not received consistent pitching over the last two weeks. Houston clearly enters this matchup with more momentum and better offensive production.

Best Picks

Astros Moneyline
Over 9 Runs

Prediction: Astros 6, Reds 4

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