Houston Astros vs Cleveland Guardians Picks and Prediction for Monday April 20 2026

Astros Preview

In Monday night MLB action, the Houston Astros will travel to Progressive Field to take on the Cleveland Guardians. Be ready for the baseball season with all of our MLB predictions. The Astros (8-15) are looking to snap a four-game losing streak and are trapped in the AL West Division cellar. On Sunday, Houston 2B Jose Altuve collected three hits and scored a run during a 7-5 home loss versus St. Louis in 10 innings.

Twenty-seven year old lefty Colton Gordon (0-0 9.95 ERA) will make his second start of the year for the Astros. In his first start, Gordon (3.2 IP) gave up eight hits and four runs during a 7-6 home victory versus Colorado.

Guardians Preview

The Cleveland Guardians have won seven of their first ten home games and hold a half-game lead over Detroit for the top spot in the AL Central Division. On Sunday, Cleveland DH Jose Ramirez hit two solo shots and SS Brayan Rocchio went 3-for-4 with three RBIs during an 8-4 home victory versus Baltimore. 2B Juan Brito added a two-run double and scored for the Guardians.

The Guardians will give the nod to twenty-six year old righty Slade Cecconi (0-2 5.03 ERA) on Monday. Last time out, Cecconi (4 IP) issued five walks and allowed one run during a 5-3 road loss against St. Louis.

Astros vs Guardians Pick

Houston RP Josh Hader (biceps) threw a live batting practice session on Tuesday and hopes to make his season debut late next month Through 23 games, Houston ranks 3rd in OPS and 3rd in runs scored. For the season, Cleveland ranks 19th in OPS and 18th in runs scored. Take the under. Final Score Prediction, Cleveland Guardians win 4-2.

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