Houston Astros vs Los Angeles Angels Picks and Predictions for Friday September 26 2025

By: Jeremy O'Quinn Published 09/26/2025, 12:30 AM ET
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Astros Preview

The Houston Astros are heading to Angel Stadium on Friday, September 26, where they will take on the Los Angeles Angels. Get the rest of our free MLB picks here! The Astros currently sit with an 85-74 record. Houston is averaging 4.2 runs per game, with a .250 team batting average, 1,336 hits, and 172 home runs scored on the year. Their bullpen holds a team ERA of 3.88, allowing 7.9 hits per nine innings and posting a collective WHIP of 1.22. Jason Alexander will be the starting pitcher for the Astros in this game, he enters with a 4-2 record, a 4.83 ERA, and a 1.39 WHIP over 72.2 innings pitched.

Angels Preview

The Angels currently sit at 71-87. Los Angeles is batting just .226 this season, scoring about 4.19 runs per game, accumulating 1,185 hits and 220 home runs. Their bullpen has been a challenge, with an ERA of 4.86. Kyle Hendricks will serve as the Angels’ starting pitcher, he owns an 8-10 record with a 4.79 ERA and a 1.28 WHIP for the season. The Angels will be looking to play spoiler against their division rivals, while Houston will be aiming to keep pace in the playoff race.

Angels vs Astros Pick

The Los Angeles Angels heading into Friday night, losing eight of their last 10 games , while the Astros hope to flip the page after a recent five game losing skid. Expect a hungry Astros team to come out and cover the -1.5 spread here. Final score prediction, Astros win 5-3.

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