Houston Astros vs Minnesota Twins Picks and Prediction for Wednesday May 20 2026
The Houston Astros travel to face the Minnesota Twins on Wednesday May 20, 2026, at Target Field in Minneapolis, Minnesota. First pitch is scheduled for 1:40 PM ET with television coverage available on MLB.TV. At the time of this writing the odds were not released. Be sure to check out our free MLB picks.
Starting Pitchers
Mike Burrows is expected to start for Houston in this matchup. The right-hander enters the game with a 2-5 record, a 5.72 ERA, and a 1.53 WHIP over 50.1 innings pitched. He has allowed 60 hits while recording 46 strikeouts and 17 walks while surrendering 10 home runs. Minnesota is expected to counter with Joe Ryan, who carries a 2-3 record, a 3.20 ERA, and a 1.01 WHIP through 50.2 innings. He has allowed 37 hits while striking out 52 batters and walking 14 while giving up only three home runs.
Houston Trying to Regain Momentum
The Astros enter Wednesday with a 19-30 overall record and a 7-16 road record. Houston recently lost to Minnesota 6-3 and also recently lost to Texas 8-0 and Seattle 8-3. The Astros did recently win over Texas by scores of 4-1 and 2-0 during this stretch, but the club has struggled to maintain consistency over the last several games.
Houston is batting .250 as a team with 215 runs scored and 412 hits this season. The Astros have hit 59 home runs while posting a .327 on-base percentage and a .411 slugging percentage. On the mound, Houston owns a 5.45 ERA and a 1.55 WHIP while opponents are batting .257 against the pitching staff. The Astros have issued 245 walks while recording 420 strikeouts this season.
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One major issue for Houston entering this game is run prevention. The Astros currently carry a 5.45 team ERA and a 1.55 WHIP, both higher than Minnesota’s numbers entering Wednesday. Houston has also struggled away from home with only seven road victories this season, making this another difficult matchup on the road against a team coming off consecutive wins.
Minnesota Looking to Keep Winning Streak Alive
The Twins enter this contest with a 22-26 overall record and a 14-13 home record. Minnesota recently won over Houston 6-3 and has now won three of its last five games overall. During that stretch, the Twins also recently won over Milwaukee 5-4 and Miami 9-1 while recently losing to Milwaukee by scores of 2-1 and 3-2. Minnesota has continued to stay competitive in close games while also producing several strong offensive performances recently.
The Twins are batting .236 as a team with 225 runs scored and 377 hits this season. Minnesota has hit 53 home runs while posting a .324 on-base percentage and a .387 slugging percentage. The pitching staff carries a 4.32 ERA and a 1.35 WHIP while opponents are batting .246 against them. Minnesota has also recorded 360 strikeouts and issued 177 walks this season.
One major strength for Minnesota entering this matchup is the advantage on the mound. The Twins own the lower team ERA and WHIP while Wednesday’s starting pitcher enters with significantly stronger numbers than Houston’s starter. Minnesota has also done a better job limiting home runs and controlling opposing hitters throughout the season compared to Houston.
Houston Astros vs Minnesota Twins Picks and Prediction
Houston Astros vs Minnesota Twins Pick
- Pick: Minnesota Twins Moneyline
Minnesota enters this matchup with the stronger pitching numbers both individually and as a team. The Twins already defeated Houston 6-3 in the series opener and continue to play better baseball overall entering Wednesday. Houston has struggled badly on the road with only seven wins away from home and currently carries a 5.45 team ERA. Minnesota also holds the advantage in WHIP and opponent batting average, making the Twins the stronger side in this matchup.
Houston Astros vs Minnesota Twins Total Pick
- Pick: Take the over if the total is set at 8.5
I would lean toward the over because Houston’s pitching staff has struggled consistently throughout the season. The Astros own a 5.45 ERA and a 1.55 WHIP while allowing opponents to hit .257 against them. Houston has also allowed six or more runs in three of its last five games. Minnesota recently scored six runs against the Astros and has shown the ability to generate offense in several recent matchups. With Houston capable of contributing offense as well through its power numbers, this matchup could move above a moderate total.
Final Score Prediction: Minnesota Twins 6 – Houston Astros 4
This prediction was written before the completion of game play on Tuesday.
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