Houston Astros vs. Toronto Blue Jays Picks and Predictions for Wednesday September 10, 2025

By: Dylan Hellebrand Published 09/10/2025, 12:25 AM ET
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On Wednesday, the Houston Astros (78-66) face off against the Toronto Blue Jays (82-61) at Rogers Centre in Toronto, Ontario. This game will be aired on Space City Home Network at Sportsnet. Keep up to date with all the MLB action, with our MLB picks.

Game Information For Astros vs Blue Jays

  • September 10, 2025, 7:07pm EST, Rogers Centre, Space City Home Network/Sportsnet
  • 70° sunny at start time

Toronto Blue Jays Form & Recent Results

Toronto comes into this matchup on a two-game losing streak, but has won three of their last five games prior to their series opener against Houston. In Sunday’s 4-3 defeat against the Yankees, Blue Jays’ starter Max Scherzer lasted 4.1 innings on the mound. During his outing, he gave up three hits and was charged with four earned runs. Control was an issue, as he walked four batters but also managed to strike out eight. Offensively, George Springer has been the team’s top power hitter this season, leading Toronto with 27 home runs. Vladimir Guerrero Jr. follows closely behind, having hit 23 home runs so far. When it comes to driving in runs, Bo Bichette stands out as the Blue Jays’ leader, racking up a team-high 93 RBIs. Bichette is also the club’s most consistent hitter, boasting a .311 batting average over the course of the year. Recently, the Blue Jays’ offense has been clicking, with the team averaging 7.2 runs scored per game over their last five games, a surge that has kept them firmly in the mix for first place in the AL East. As they return home, they hope to keep building on their strong offensive performances; overall this season, Toronto averages 5 runs per game.

Houston Astros Form & Recent Results

Houston enters this game on a one-game losing streak and has dropped three of their last five games prior to their series opener against Toronto. In Sunday’s 4-2 defeat against Texas, Astros pitcher Framber Valdez put in a solid effort, tossing seven innings in which he gave up five hits and three earned runs. He walked just one batter and recorded five strikeouts during his outing. On offense, Jose Altuve is leading the team in home runs this season, having sent 24 balls over the fence. Close behind is Christian Walker, who has contributed 22 home runs, making him the team’s second-highest homerun hitter. Walker also leads Houston in RBIs, having driven in 76 runs so far this year. Jeremy Pena has been the most consistent at the plate, holding the highest batting average on the team at .304. Defensively, the Astros have struggled recently, allowing an average of 4.6 runs per game over their last five games as they try to improve their performance on the road. Collectively, the Astros are averaging 4.2 runs scored per game so far this season.

Starting Pitchers For Blue Jays vs Astros 

  • Houston’s Jason Alexander on the road: 4-0, 3.94 ERA
  • Toronto’s Shane Bieber at home: 0-1, 3.38 ERA

Blue Jays vs Astros Picks and Prediction

Earlier in April, the Astros completed a sweep of the Blue Jays, and now Toronto will be hoping to use that recent history as motivation to turn things around. With Shane Bieber taking the mound for the Blue Jays, the team is aiming to support him, especially as their offense has shown clear signs of improvement in recent games. On the other side, Houston will counter with Jason Alexander as their starting pitcher. Alexander has already secured four wins on the road this season and will be looking to notch his fifth as the Astros try to continue their dominance over Toronto. Final Score Prediction, Toronto Blue Jays win 2-1.

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